Robin J Shattock
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Explore the profile of Robin J Shattock including associated specialties, affiliations and a list of published articles.
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194
Citations
4933
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Recent Articles
1.
Peeler D, Sun R, Kutahya C, Peschke P, Zhou K, Brachi G, et al.
Adv Mater
. 2025 Feb;
:e2417290.
PMID: 40018867
Two-photon polymerization (2PP) 3D printing enables top-down biomaterial synthesis with nanoscale spatial resolution for de novo design of monodisperse injectable drug delivery systems. Spatiotemporal Controlled Release Inks of Biocompatible polyEsters...
2.
Barton R, Tregoning J, Wang Z, Goncalves-Carneiro D, Patel R, McKay P, et al.
Mol Ther Nucleic Acids
. 2025 Jan;
36(1):102400.
PMID: 39759876
Self-amplifying RNA (saRNA) is an extremely promising platform because it can produce more protein for less RNA. We used a sort and sequence approach to identify host cell factors associated...
3.
Pollock K, Cheeseman H, McFarlane L, Day S, Tolazzi M, Turner H, et al.
EBioMedicine
. 2025 Jan;
112:105544.
PMID: 39753033
Background: We report findings from an experimental medicine study of rationally designed prefusion stabilised native-like HIV envelope glycoprotein (Env) immunogens, representative of global circulating strains, delivered by sequential intramuscular injection....
4.
Lombardi L, Granger L, Shattock R, Williams D
J Org Chem
. 2024 Nov;
90(4):1467-1477.
PMID: 39611613
Protein-protein interactions (PPIs) are pivotal in regulating cellular functions and life processes, making them promising therapeutic targets in modern medicine. Despite their potential, developing PPI inhibitors poses significant challenges due...
5.
Kitandwe P, Rogers P, Hu K, Nayebare O, Blakney A, McKay P, et al.
Vaccines (Basel)
. 2024 Oct;
12(10).
PMID: 39460255
Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that causes high fetal and neonatal mortality rates in ruminants and sometimes severe to fatal complications like encephalitis and hemorrhagic fever...
6.
Barbieri B, Peeler D, Samnuan K, Day S, Hu K, Sallah H, et al.
J Control Release
. 2024 Aug;
374:280-292.
PMID: 39142355
Lipid nanoparticle (LNP) formulation plays a vital role in RNA vaccine delivery. However, further optimisation of self-amplifying RNA (saRNA) vaccine formulation could help enhance seroconversion rates in humans and improve...
7.
Rosenkrands I, Olsen A, Knudsen S, Dehari N, Juel H, Cheeseman H, et al.
EBioMedicine
. 2024 May;
104:105140.
PMID: 38744110
Background: Chlamydia trachomatis (CT) Major Outer Membrane Protein (MOMP) holds a neutralising epitope in the Variable Domain 4 (VD4), and this region's immune dominance during infection is well known. This...
8.
Chen Y, Lin X, Liu X, Liu Y, Bui-Le L, Blakney A, et al.
Biomacromolecules
. 2024 Apr;
25(5):2965-2972.
PMID: 38682378
Nucleic acid therapeutics have attracted recent attention as promising preventative solutions for a broad range of diseases. Nonviral delivery vectors, such as cationic polymers, improve the cellular uptake of nucleic...
9.
Pollock K, Borges A, Cheeseman H, Rosenkrands I, Schmidt K, Sondergaard R, et al.
Lancet Infect Dis
. 2024 Apr;
24(8):829-844.
PMID: 38615673
Background: There is no vaccine against the major global pathogen Chlamydia trachomatis; its different serovars cause trachoma in the eye or chlamydia in the genital tract. We did a clinical...
10.
Dastgerdi N, Gumus N, Bayraktutan H, Jackson D, Polra K, McKay P, et al.
Nanoscale Adv
. 2024 Feb;
6(5):1409-1422.
PMID: 38419881
Therapeutic self-amplifying RNA (saRNA) is a promising approach for disease treatment, as it can be administered in lower doses than messenger RNA (mRNA) to achieve comparable protein production levels. However,...