Roberto Pacifici
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Explore the profile of Roberto Pacifici including associated specialties, affiliations and a list of published articles.
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67
Citations
3631
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Recent Articles
11.
Yu M, Pal S, Paterson C, Li J, Tyagi A, Adams J, et al.
J Clin Invest
. 2021 Feb;
131(4).
PMID: 33586672
Estrogen deficiency causes a gut microbiome-dependent expansion of BM Th17 cells and TNF-α-producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF stimulate RANKL expression and activity,...
12.
Tyagi A, Darby T, Hsu E, Yu M, Pal S, Dar H, et al.
Elife
. 2021 Jan;
10.
PMID: 33432923
Genetic factors account for the majority of the variance of human bone mass, but the contribution of non-genetic factors remains largely unknown. By utilizing maternal/offspring transmission, cohabitation, or fecal material...
13.
Pacifici R
J Clin Endocrinol Metab
. 2020 Nov;
106(3):636-645.
PMID: 33254225
Exposed surfaces of mammals are colonized with 100 trillion indigenous bacteria, fungi, and viruses, creating a diverse ecosystem known as the human microbiome. The gut microbiome is the richest microbiome...
14.
Bellissimo M, Roberts J, Jones D, Liu K, Taibl K, Uppal K, et al.
Nutrients
. 2020 Oct;
12(10).
PMID: 33081124
Bone is a dynamic tissue that is in a constant state of remodeling. Bone turnover markers (BTMs), procollagen type I N-terminal propeptide (P1NP) and C-terminal telopeptides of type I collagen...
15.
Bellissimo M, Ziegler T, Jones D, Liu K, Fernandes J, Roberts J, et al.
Clin Nutr
. 2020 Jul;
40(2):467-475.
PMID: 32620447
Background & Aims: There is a considerable degree of variation in bone mineral density (BMD) within populations. Use of plasma metabolomics may provide insight into established and novel determinants of...
16.
Yu M, Tyagi A, Li J, Adams J, Denning T, Weitzmann M, et al.
Nat Commun
. 2020 Jan;
11(1):468.
PMID: 31980603
Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota...
17.
Li J, Yu M, Pal S, Tyagi A, Dar H, Adams J, et al.
J Clin Invest
. 2020 Jan;
130(4):1767-1781.
PMID: 31917685
Parathyroid hormone (PTH) is a critical regulator of skeletal development that promotes both bone formation and bone resorption. Using microbiota depletion by wide-spectrum antibiotics and germ-free (GF) female mice, we...
18.
Zaiss M, Jones R, Schett G, Pacifici R
J Clin Invest
. 2019 Jul;
129(8):3018-3028.
PMID: 31305265
The gut microbiome is a key regulator of bone health that affects postnatal skeletal development and skeletal involution. Alterations in microbiota composition and host responses to the microbiota contribute to...
19.
Tyagi A, Yu M, Darby T, Vaccaro C, Li J, Owens J, et al.
Immunity
. 2018 Nov;
49(6):1116-1131.e7.
PMID: 30446387
Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we examined the impact of supplementation with Lactobacillus rhamnosus GG (LGG) on bone homeostasis in eugonadic young mice. Micro-computed tomography...
20.
Li J, Yu M, Tyagi A, Vaccaro C, Hsu E, Adams J, et al.
J Bone Miner Res
. 2018 Nov;
34(2):349-360.
PMID: 30399207
Primary hyperparathyroidism (PHPT) is a condition where elevated PTH levels lead to bone loss, in part through increased production of the osteoclastogenic factor IL-17A, by bone marrow (BM) T-helper 17...