M Neale Weitzmann
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Explore the profile of M Neale Weitzmann including associated specialties, affiliations and a list of published articles.
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111
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4733
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Recent Articles
1.
Dabeer S, Tripathi A, Weiss D, Vikulina T, Ofotokun I, Weitzmann M
J Infect Dis
. 2024 Dec;
PMID: 39726127
Background: Antiretroviral therapy (ART) causes osteoporosis and bone fractures, increasing morbidity and mortality in people living with HIV (PLH). ART induces immune reconstitution bone loss (IRBL), an inflammatory reaction associated...
2.
Tripathi A, Dabeer S, Song J, Vikulina T, Roser-Page S, Alvarez J, et al.
Cell Death Dis
. 2024 Dec;
15(12):907.
PMID: 39695103
Sickle cell disease (SCD) is a severe hematological disorder characterized by erythrocyte sickling that causes significant morbidity and mortality. Skeletal complications of SCD include a high incidence of bone loss,...
3.
Linoleic acid blunts early osteoblast differentiation and impairs oxidative phosphorylation in vitro
Nesbeth P, Ziegler T, Tripathi A, Dabeer S, Weiss D, Hao L, et al.
Prostaglandins Leukot Essent Fatty Acids
. 2024 May;
201:102617.
PMID: 38788347
Background: Linoleic acid (LNA), an essential polyunsaturated fatty acid (PUFA), plays a crucial role in cellular functions. However, excessive intake of LNA, characteristic of Western diets, can have detrimental effects...
4.
Pal S, Morgan X, Dar H, Gacasan C, Patil S, Stoica A, et al.
J Clin Invest
. 2024 Mar;
134(10).
PMID: 38530358
Gender-affirming hormone therapy (GAHT) is often prescribed to transgender (TG) adolescents to alleviate gender dysphoria, but the effect of GAHT on the growing skeleton is unclear. We found GAHT to...
5.
Zheng H, Li Q, Li S, Li Z, Brotto M, Weiss D, et al.
Elife
. 2023 Sep;
12.
PMID: 37672386
While mitochondria in different tissues have distinct preferences for energy sources, they are flexible in utilizing competing substrates for metabolism according to physiological and nutritional circumstances. However, the regulatory mechanisms...
6.
Dar H, Perrien D, Pal S, Stoica A, Uppuganti S, Nyman J, et al.
J Clin Invest
. 2023 Mar;
133(8).
PMID: 36881482
IL-17A (IL-17), a driver of the inflammatory phase of fracture repair, is produced locally by several cell lineages including γδ T cells and Th17 cells. However, the origin of these...
7.
Mehta C, Hagen K, Rubtsova A, Lahiri C, Michopoulos V, Moran C, et al.
PLoS One
. 2022 Aug;
17(8):e0272608.
PMID: 35921353
Purpose: We describe the rationale for and design of an innovative, nested, tripartite prospective observational cohort study examining whether relative estrogen insufficiency-induced inflammation amplifies HIV-induced inflammation to cause end organ...
8.
Roser-Page S, Weiss D, Vikulina T, Yu M, Pacifici R, Weitzmann M
JBMR Plus
. 2022 Jul;
6(7):e10636.
PMID: 35866149
Cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase (PDE) inhibitors such as pentoxifylline (PTX) suppress cAMP degradation and promote cAMP-dependent signal transduction. PDE inhibitors increase bone formation and bone mass in preclinical models...
9.
Yin M, Hoover D, Shi Q, Tien P, Cohen M, Kassaye S, et al.
AIDS
. 2022 Jun;
36(12):1683-1688.
PMID: 35730385
Background: Fracture rates have been reported to be higher among older women living with HIV (WLWH) than HIV- women. Hormone therapy with estrogen can reduce vasomotor symptoms (VMS) associated with...
10.
The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone
Pal S, Perrien D, Yumoto T, Faccio R, Stoica A, Adams J, et al.
J Clin Invest
. 2022 May;
132(12).
PMID: 35503658
Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by the gut microbiome influences cancer progression, but the...