Role of Gut Microbiota in the Skeletal Response to PTH

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2020 Nov 30

PMID 33254225

Citations 11

Authors

Roberto Pacifici

Affiliations

Soon will be listed here.

Abstract

Exposed surfaces of mammals are colonized with 100 trillion indigenous bacteria, fungi, and viruses, creating a diverse ecosystem known as the human microbiome. The gut microbiome is the richest microbiome and is now known to regulate postnatal skeletal development and the activity of the major endocrine regulators of bone. Parathyroid hormone (PTH) is one of the bone-regulating hormone that requires elements of the gut microbiome to exert both its bone catabolic and its bone anabolic effects. How the gut microbiome regulates the skeletal response to PTH is object of intense research. Involved mechanisms include absorption and diffusion of bacterial metabolites, such as short-chain fatty acids, and trafficking of immune cells from the gut to the bone marrow. This review will focus on how the gut microbiome communicates and regulates bone marrow cells in order to modulate the skeletal effects of PTH.

Citing Articles

Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies.

Ticinesi A, Siniscalchi C, Meschi T, Nouvenne A Osteoporos Int. 2024; 36(2):167-191.

PMID: 39643654 DOI: 10.1007/s00198-024-07320-0.

Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients: Is There a Novel Relationship?.

Garagarza C, Valente A, Queiros C, Neto I, Sebastiao J, Gomes M Int J Mol Sci. 2024; 25(4).

PMID: 38396685 PMC: 10888856. DOI: 10.3390/ijms25042006.

Endocrine Disruptor-Induced Bone Damage Due to Hormone Dysregulation: A Review.

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Pivotal Role of Intestinal Microbiota and Intraluminal Metabolites for the Maintenance of Gut-Bone Physiology.

Gruner N, Ortlepp A, Mattner J Int J Mol Sci. 2023; 24(6).

PMID: 36982235 PMC: 10048911. DOI: 10.3390/ijms24065161.

Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis.

Zhou R, Zhang Y, Cao M, Liu C, Rui Y, Li Y J Bone Miner Metab. 2023; 41(2):145-162.

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