Roberto Pacifici
Overview
Explore the profile of Roberto Pacifici including associated specialties, affiliations and a list of published articles.
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67
Citations
3631
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Recent Articles
1.
Pal S, Morgan X, Dar H, Gacasan C, Patil S, Stoica A, et al.
J Clin Invest
. 2024 Mar;
134(10).
PMID: 38530358
Gender-affirming hormone therapy (GAHT) is often prescribed to transgender (TG) adolescents to alleviate gender dysphoria, but the effect of GAHT on the growing skeleton is unclear. We found GAHT to...
2.
Okoro P, Orwoll E, Huttenhower C, Morgan X, Kuntz T, McIver L, et al.
Front Endocrinol (Lausanne)
. 2023 Oct;
14:1237727.
PMID: 37810879
The gut microbiome affects the inflammatory environment through effects on T-cells, which influence the production of immune mediators and inflammatory cytokines that stimulate osteoclastogenesis and bone loss in mice. However,...
3.
Tao H, Dar H, Tian C, Banerjee S, Glazer E, Srinivasan S, et al.
Redox Biol
. 2023 Sep;
67:102892.
PMID: 37741044
Males show higher incidence and severity than females in hepatic injury and many liver diseases, but the mechanisms are not well understood. Ferroptosis, an iron-mediated lipid peroxidation-dependent death, plays an...
4.
Evenepoel P, Stenvinkel P, Shanahan C, Pacifici R
Nat Rev Nephrol
. 2023 Jul;
19(10):646-657.
PMID: 37488276
Two decades ago, Kidney Disease: Improving Global Outcomes coined the term chronic kidney disease-mineral and bone disorder (CKD-MBD) to describe the syndrome of biochemical, bone and extra-skeletal calcification abnormalities that...
5.
Tao H, Dar H, Tian C, Banerjee S, Glazer E, Srinivasan S, et al.
bioRxiv
. 2023 Jul;
PMID: 37425728
Males show higher incidence and severity than females in hepatic injury and many liver diseases, but the mechanisms are not well understood. Ferroptosis, an iron-mediated lipid peroxidation-dependent death, plays an...
6.
Roberts J, Yu M, Viggeswarapu M, Arnst J, Pacifici R, Beck Jr G
JCI Insight
. 2023 Apr;
8(10).
PMID: 37079375
The intake of dietary phosphate far exceeds recommended levels; however, the long-term health consequences remain relatively unknown. Here, the chronic physiological response to sustained elevated and reduced dietary phosphate consumption...
7.
Dar H, Perrien D, Pal S, Stoica A, Uppuganti S, Nyman J, et al.
J Clin Invest
. 2023 Mar;
133(8).
PMID: 36881482
IL-17A (IL-17), a driver of the inflammatory phase of fracture repair, is produced locally by several cell lineages including γδ T cells and Th17 cells. However, the origin of these...
8.
Xiong J, Liao J, Liu X, Zhang Z, Adams J, Pacifici R, et al.
Nat Commun
. 2022 Aug;
13(1):4820.
PMID: 35973996
Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B receptor (TrkB) are expressed in human osteoblasts and mediate fracture healing. BDNF/TrkB signaling activates Akt that phosphorylates and inhibits asparagine endopeptidase...
9.
Roser-Page S, Weiss D, Vikulina T, Yu M, Pacifici R, Weitzmann M
JBMR Plus
. 2022 Jul;
6(7):e10636.
PMID: 35866149
Cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase (PDE) inhibitors such as pentoxifylline (PTX) suppress cAMP degradation and promote cAMP-dependent signal transduction. PDE inhibitors increase bone formation and bone mass in preclinical models...
10.
The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone
Pal S, Perrien D, Yumoto T, Faccio R, Stoica A, Adams J, et al.
J Clin Invest
. 2022 May;
132(12).
PMID: 35503658
Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by the gut microbiome influences cancer progression, but the...