Robert V Williams
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Explore the profile of Robert V Williams including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
27
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Recent Articles
1.
Williams R, Guay K, Hurlbut Lesk O, Clerico E, Hebert D, Gierasch L
Proc Natl Acad Sci U S A
. 2024 Aug;
121(34):e2315009121.
PMID: 39133860
The enzyme UDP-glucose: glycoprotein glucosyltransferase (UGGT) is the gatekeeper of protein folding within the endoplasmic reticulum (ER). One-third of the human proteome traverses the ER where folding and maturation are...
2.
Williams R, Rogals M, Eletsky A, Huang C, Morris L, Moremen K, et al.
J Magn Reson
. 2022 Nov;
345:107336.
PMID: 36442299
Not all proteins are amenable to uniform isotopic labeling with C and N, something needed for the widely used, and largely deductive, triple resonance assignment process. Among them are proteins...
3.
Guay K, Williams R, Hebert D
EMBO J
. 2022 Nov;
41(24):e113003.
PMID: 36377534
Maturation of membrane proteins is complicated by the need to fold in three distinct environments. While much is known about folding in the two aqueous milieus constituted by cytoplasm and...
4.
Shao N, Fan Y, Chou C, Yavari S, Williams R, Jonathan Amster I, et al.
Commun Biol
. 2022 Oct;
5(1):1113.
PMID: 36266535
Methanogens and anaerobic methane-oxidizing archaea (ANME) are important players in the global carbon cycle. Methyl-coenzyme M reductase (MCR) is a key enzyme in methane metabolism, catalyzing the last step in...
5.
Williams R, Huang C, McDermott C, Ahmed T, Columbus L, Moremen K, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2202992119.
PMID: 36251991
-glycosylation is a common posttranslational modification of secreted proteins in eukaryotes. This modification targets asparagine residues within the consensus sequence, N-X-S/T. While this sequence is required for glycosylation, the initial...
6.
Williams R, Huang C, Moremen K, Jonathan Amster I, Prestegard J
Sci Rep
. 2022 Aug;
12(1):14769.
PMID: 36042257
Human roundabout 1 (hRobo1) is an extracellular receptor glycoprotein that plays important roles in angiogenesis, organ development, and tumor progression. Interaction between hRobo1 and heparan sulfate (HS) has been shown...
7.
Williams R, Jonathan Amster I
Methods Mol Biol
. 2021 Oct;
2303:87-92.
PMID: 34626372
Traveling wave ion-mobility mass spectrometry (TWIMS) combined with native mass spectrometry (MS) has emerged as a powerful tool for analyzing biomolecules, including complexes of protein and heparan sulfate (HS). This...
8.
Rogals M, Yang J, Williams R, Moremen K, Jonathan Amster I, Prestegard J
Glycobiology
. 2020 Sep;
31(4):425-435.
PMID: 32902634
Preparation of samples for nuclear magnetic resonance (NMR) characterization of larger proteins requires enrichment with less abundant, NMR-active, isotopes such as 13C and 15N. This is routine for proteins that...
9.
Williams R, Yang J, Moremen K, Jonathan Amster I, Prestegard J
J Biomol NMR
. 2019 May;
73(3-4):191-198.
PMID: 31041649
Residual dipolar couplings (RDCs) provide both structural and dynamical information useful in the characterization of biological macromolecules. While most data come from the interaction of simple pairs of directly bonded...