Alexander Eletsky
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Explore the profile of Alexander Eletsky including associated specialties, affiliations and a list of published articles.
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38
Citations
1146
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Recent Articles
1.
Williams R, Rogals M, Eletsky A, Huang C, Morris L, Moremen K, et al.
J Magn Reson
. 2022 Nov;
345:107336.
PMID: 36442299
Not all proteins are amenable to uniform isotopic labeling with C and N, something needed for the widely used, and largely deductive, triple resonance assignment process. Among them are proteins...
2.
Rogals M, Eletsky A, Huang C, Morris L, Moremen K, Prestegard J
ACS Chem Biol
. 2022 Nov;
17(12):3527-3534.
PMID: 36417668
Glycans attached to glycoproteins can contribute to stability, mediate interactions with other proteins, and initiate signal transduction. Glycan conformation, which is critical to these processes, is highly variable and often...
3.
Berardinelli S, Eletsky A, Valero-Gonzalez J, Ito A, Manjunath R, Hurtado-Guerrero R, et al.
J Biol Chem
. 2022 May;
298(6):102047.
PMID: 35597280
Thrombospondin type-1 repeats (TSRs) are small protein motifs containing six conserved cysteines forming three disulfide bonds that can be modified with an O-linked fucose. Protein O-fucosyltransferase 2 (POFUT2) catalyzes the...
4.
Khaje N, Eletsky A, Biehn S, Mobley C, Rogals M, Kim Y, et al.
Commun Biol
. 2022 May;
5(1):452.
PMID: 35551273
High resolution hydroxyl radical protein footprinting (HR-HRPF) is a mass spectrometry-based method that measures the solvent exposure of multiple amino acids in a single experiment, offering constraints for experimentally informed...
5.
Kim H, Eletsky A, Gonzalez K, van der Wel H, Strauch E, Prestegard J, et al.
Biochemistry
. 2020 Apr;
59(15):1527-1536.
PMID: 32227851
Skp1 is an adapter that links F-box proteins to cullin-1 in the Skp1/cullin-1/F-box (SCF) protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and subsequent protein degradation....
6.
Chalmers G, Eletsky A, Morris L, Yang J, Tian F, Woods R, et al.
J Mol Biol
. 2019 Apr;
431(12):2369-2382.
PMID: 31034888
Characterization of proteins using NMR methods begins with assignment of resonances to specific residues. This is usually accomplished using sequential connectivities between nuclear pairs in proteins uniformly labeled with NMR...
7.
Rosario-Cruz Z, Eletsky A, Daigham N, Al-Tameemi H, Swapna G, Kahn P, et al.
J Biol Chem
. 2019 Jan;
294(11):4027-4044.
PMID: 30655293
As complications associated with antibiotic resistance have intensified, copper (Cu) is attracting attention as an antimicrobial agent. Recent studies have shown that copper surfaces decrease microbial burden, and host macrophages...
8.
Moure M, Eletsky A, Gao Q, Morris L, Yang J, Chapla D, et al.
ACS Chem Biol
. 2018 Aug;
13(9):2560-2567.
PMID: 30063822
An enzyme- and click chemistry-mediated methodology for the site-specific nitroxide spin labeling of glycoproteins has been developed and applied. The procedure relies on the presence of single N-glycosylation sites that...
9.
Xu X, Eletsky A, Sheikh M, Prestegard J, West C
Biochemistry
. 2017 Dec;
57(5):511-515.
PMID: 29251491
Cullin-ring-ligases mediate protein polyubiquitination, a signal for degradation in the 26S proteasome. The CRL1 class consists of Skp1/cullin-1/F-box protein/Rbx1 (SCF) complexes that cyclically associate with ubiquitin-E2 to build the polyubiquitin...
10.
Bhardwaj G, Mulligan V, Bahl C, Gilmore J, Harvey P, Cheneval O, et al.
Nature
. 2016 Sep;
538(7625):329-335.
PMID: 27626386
Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes that have evolved to fit precisely into binding pockets on their targets. Such peptides can have excellent pharmaceutical...