Analysis of Protein-Glycosaminoglycan Interactions Using Traveling Wave Ion-Mobility Mass Spectrometry

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2021 Oct 9

PMID 34626372

Authors

Robert V Williams

I Jonathan Amster

Affiliations

Soon will be listed here.

Abstract

Traveling wave ion-mobility mass spectrometry (TWIMS) combined with native mass spectrometry (MS) has emerged as a powerful tool for analyzing biomolecules, including complexes of protein and heparan sulfate (HS). This technique allows determination of the stoichiometry of the protein-HS interaction and information on the overall 3D molecular envelope.

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