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Robert S Hodges

Explore the profile of Robert S Hodges including associated specialties, affiliations and a list of published articles. Areas
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Articles 108
Citations 2389
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Recent Articles
1.
Zhao R, Ma X, Bai L, Li X, Mamouni K, Yang Y, et al.
Neoplasia . 2021 Nov; 23(12):1261-1274. PMID: 34781084
A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. It is imperative to discover effective therapies to...
2.
Mant C, Jiang Z, Gera L, Davis T, Hodges R
J Med Chem Drug Des . 2021 Aug; 2(2). PMID: 34377965
We designed and synthesized two series of five 26-residue amphipathic α-helical cationic antimicrobial peptides (AMPs) with five or six positively charged residues (D-Lys, L-Dab (2,4-diaminobutyric acid) or L-Dap (2,3-diaminopropionic acid))...
3.
Mant C, Jiang Z, Gera L, Davis T, Nelson K, Bevers S, et al.
J Med Chem . 2019 Mar; 62(7):3354-3366. PMID: 30848594
We have designed de novo and synthesized ten 26-residue D-conformation amphipathic α-helical cationic antimicrobial peptides (AMPs), seven with "specificity determinants", which provide specificity for prokaryotic cells over eukaryotic cells. The...
4.
Mant C, Byars A, Ankarlo S, Jiang Z, Hodges R
J Chromatogr A . 2018 Sep; 1574:60-70. PMID: 30220427
We are currently examining the potential of amphipathic cationic α-helical peptides as a new generation of peptide standards for both cation-exchange high-performance liquid chromatography and reversed-phase chromatography. Thus, amphipathic peptides...
5.
Jiang Z, Mant C, Vasil M, Hodges R
Chem Biol Drug Des . 2017 Jun; 91(1):75-92. PMID: 28636788
We have designed de novo and synthesized eight 26-residue all D-conformation amphipathic α-helical cationic antimicrobial peptides (AMPs), four with "specificity determinants" which provide specificity for prokaryotic cells over eukaryotic cells...
6.
Murschel F, Fortier C, Jolicoeur M, Hodges R, De Crescenzo G
Biomacromolecules . 2017 Jan; 18(3):965-975. PMID: 28122454
We have developed a heterodimeric coiled-coil system based on two complementary peptides, namely (EVSALEK) and (KVSALKE), or E and K, for the attachment of E-tagged biomolecules onto K-decorated biomaterials. We...
7.
Romantsov T, Culham D, Caplan T, Garner J, Hodges R, Wood J
Mol Microbiol . 2016 Nov; 103(3):469-482. PMID: 27802568
Osmosensing transporter ProP protects bacteria from osmotically induced dehydration by mediating the uptake of zwitterionic osmolytes. ProP activity is a sigmoidal function of the osmolality. ProP orthologues share an extended,...
8.
Mant C, Hodges R
Curr Protoc Protein Sci . 2016 Aug; 85:11.6.1-11.6.16. PMID: 27479502
Reversed-phase high-performance liquid chromatography (RP-HPLC) is of fundamental importance to the isolation and separation of peptides, proteins, and other biomolecules. Hence, there is a continuing high demand for the development...
9.
Jiang Z, Gera L, Mant C, Hirsch B, Yan Z, Shortt J, et al.
Biopolymers . 2016 Jan; 106(2):144-159. PMID: 26799790
We have utilized a de novo designed two-stranded α-helical coiled-coil template to display conserved α-helical epitopes from the stem region of hemagglutinin (HA) glycoproteins of influenza A. The immunogens have...
10.
Avdieiev S, Gera L, Havrylyuk D, Hodges R, Lesyk R, Ribrag V, et al.
Bioorg Med Chem . 2014 Jul; 22(15):3815-23. PMID: 25012567
Glioblastoma (GB), the most aggressive brain tumour, and mantle cell lymphoma (MCL), a rare but very aggressive type of lymphoma, are highly resistant to chemotherapy. GB and MCL chemotherapy gives...