Robert N OMeally
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Explore the profile of Robert N OMeally including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
756
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Recent Articles
11.
Gutierrez-Hoffmann M, OMeally R, Cole R, Tiniakou E, Darrah E, Soloski M
Front Med (Lausanne)
. 2020 Oct;
7:568.
PMID: 33043033
The MHC class II antigen processing and presentation pathway has evolved to derive short amino acid peptides from proteins that enter the endocytic pathway, load them onto MHC class II...
12.
Tiniakou E, Fava A, McMahan Z, Guhr T, OMeally R, Shah A, et al.
Arthritis Rheumatol
. 2020 Mar;
72(8):1375-1384.
PMID: 32162841
Objective: Autoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality. Anti-topo...
13.
Dong Q, Majumdar G, OMeally R, Cole R, Elam M, Raghow R
Mol Cell Biochem
. 2019 Sep;
463(1-2):13-31.
PMID: 31541353
Insulin stimulates de novo lipid synthesis in the liver and in cultured hepatocytes via its ability to activate sterol regulatory element-binding protein 1c (SREBP-1c). Although PI3K-AKT-mTORC1-p70S6K-signaling kinases are known to...
14.
Camacho E, Vij R, Chrissian C, Prados-Rosales R, Gil D, OMeally R, et al.
J Biol Chem
. 2019 May;
294(27):10471-10489.
PMID: 31118223
Melanins are synthesized macromolecules that are found in all biological kingdoms. These pigments have a myriad of roles that range from microbial virulence to key components of the innate immune...
15.
Rhoads S, Monahan Z, Yee D, Leung A, Newcombe C, OMeally R, et al.
Mol Biol Cell
. 2018 Jun;
29(15):1786-1797.
PMID: 29897835
FUS (fused in sarcoma) is an abundant, predominantly nuclear protein involved in RNA processing. Under various conditions, FUS functionally associates with RNA and other macromolecules to form distinct, reversible phase-separated...
16.
Ratovitski T, OMeally R, Jiang M, Chaerkady R, Chighladze E, Stewart J, et al.
J Proteome Res
. 2017 Jun;
16(8):2692-2708.
PMID: 28653853
Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, which causes Huntington's disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified...
17.
Groves J, Maduka A, OMeally R, Cole R, Zachara N
J Biol Chem
. 2017 Feb;
292(16):6493-6511.
PMID: 28232487
The dynamic post-translational modification linked β--acetylglucosamine (-GlcNAc) regulates thousands of nuclear, cytoplasmic, and mitochondrial proteins. Cellular stress, including oxidative stress, results in increased GlcNAcylation of numerous proteins, and this increase...
18.
Lee A, Miller D, Henry R, Paruchuri V, OMeally R, Boronina T, et al.
J Proteome Res
. 2016 Sep;
15(12):4318-4336.
PMID: 27669760
O-Linked N-acetyl-β-d-glucosamine (O-GlcNAc) is a dynamic post-translational modification that modifies and regulates over 3000 nuclear, cytoplasmic, and mitochondrial proteins. Upon exposure to stress and injury, cells and tissues increase the...
19.
Sur S, Qiao Y, Fries A, OMeally R, Cole R, Kinzler K, et al.
Sci Rep
. 2015 Dec;
5:18363.
PMID: 26678960
Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple,...
20.
Dong Q, Giorgianni F, Beranova-Giorgianni S, Deng X, OMeally R, Bridges D, et al.
Biosci Rep
. 2015 Nov;
36(1):e00284.
PMID: 26589965
Sterol regulatory element binding protein-1c (SREBP-1c) is a key transcription factor that regulates genes involved in the de novo lipid synthesis and glycolysis pathways. The structure, turnover and transactivation potential...