Robert M Coates
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Explore the profile of Robert M Coates including associated specialties, affiliations and a list of published articles.
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54
Citations
1327
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Recent Articles
1.
Krasutsky S, Urbansky M, Davis C, Lherbet C, Coates R, Poulter C
J Org Chem
. 2014 Sep;
79(19):9170-8.
PMID: 25184438
The methylerythritol phosphate biosynthetic pathway, found in most Bacteria, some parasitic protists, and plant chloroplasts, converts D-glyceraldehyde phosphate and pyruvate to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), where it...
2.
Faraldos J, Coates R, Giner J
J Org Chem
. 2013 Sep;
78(20):10548-54.
PMID: 24047429
A concise preparation of the pheromone secreted by the male Colorado potato beetle [viz. (3S)-1,3-dihydroxy-3,7-dimethyl-6-octen-2-one] was accomplished in four steps starting from 2-fluoronerol or 2-fluorogeraniol. The key step in the...
3.
Vaughan M, Wang Q, Webster F, Kiemle D, Hong Y, Tantillo D, et al.
Plant Cell
. 2013 Mar;
25(3):1108-25.
PMID: 23512856
Secondary metabolites are major constituents of plant defense against herbivore attack. Relatively little is known about the cell type-specific formation and antiherbivore activities of secondary compounds in roots despite the...
4.
Sharma S, Lagisetti C, Poliks B, Coates R, Kingston D, Bane S
Biochemistry
. 2013 Mar;
52(13):2328-36.
PMID: 23473345
Paclitaxel (PTX) is a microtubule-stabilizing agent that is widely used in cancer chemotherapy. This structurally complex natural product acts by binding to β-tubulin in assembled microtubules. The 2'-hydroxyl group in...
5.
Yeo Y, Nybo S, Chittiboyina A, Weerasooriya A, Wang Y, Gongora-Castillo E, et al.
J Biol Chem
. 2012 Dec;
288(5):3163-73.
PMID: 23243312
Valerian is an herbal preparation from the roots of Valeriana officinalis used as an anxiolytic and sedative and in the treatment of insomnia. The biological activities of valerian are attributed...
6.
Koksal M, Hu H, Coates R, Peters R, Christianson D
Nat Chem Biol
. 2011 May;
7(7):431-3.
PMID: 21602811
The structure of ent-copalyl diphosphate synthase reveals three α-helical domains (α, β and γ), as also observed in the related diterpene cyclase taxadiene synthase. However, active sites are located at...
7.
Faraldos J, Kariuki B, Coates R
Org Lett
. 2011 Jan;
13(5):836-9.
PMID: 21261271
The enantiomeric 2-azapinanes, aza analogues of the pinyl carbocation intermediates in pinene biosynthesis, were synthesized from (-)- and (+)-cis-pinonic acids. The individual reactions in the 5-step sequence were Beckmann rearrangement...
8.
Koksal M, Jin Y, Coates R, Croteau R, Christianson D
Nature
. 2010 Dec;
469(7328):116-20.
PMID: 21160477
With more than 55,000 members identified so far in all forms of life, the family of terpene or terpenoid natural products represents the epitome of molecular biodiversity. A well-known and...
9.
Morrone D, Chen X, Coates R, Peters R
Biochem J
. 2010 Aug;
431(3):337-44.
PMID: 20698828
KO (kaurene oxidase) is a multifunctional cytochrome P450 catalysing three sequential oxidations in gibberellin phytohormone biosynthesis. These serve to transform the C4α methyl of the ent-kaurene olefin intermediate into the...
10.
Faraldos J, Wu S, Chappell J, Coates R
Tetrahedron
. 2010 Jul;
63(32):7733-7742.
PMID: 20617157
(+)-Germacrene A, an important intermediate in sesquiterpene biosynthesis, was isolated in pure form from a genetically engineered yeast and was characterized by chromatographic properties (TLC, GC), MS, optical rotation, UV,...