Joseph P Noel
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Explore the profile of Joseph P Noel including associated specialties, affiliations and a list of published articles.
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142
Citations
6572
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Recent Articles
1.
Nartey C, Koo H, Laurendon C, Shaik H, OMaille P, Noel J, et al.
Biochemistry
. 2024 Jan;
63(3):355-366.
PMID: 38206111
Inferring the historical and biophysical causes of diversity within protein families is a complex puzzle. A key to unraveling this problem is characterizing the rugged topography of sequence-function adaptive landscapes....
2.
Chen A, Re R, Davis T, Tran K, Moriuchi Y, Wu S, et al.
J Am Chem Soc
. 2024 Jan;
146(2):1388-1395.
PMID: 38176024
Site-specific covalent conjugation offers a powerful tool to identify and understand protein-protein interactions. In this study, we discover that sulfur fluoride exchange (SuFEx) warheads effectively crosslink the acyl carrier protein...
3.
Jiang Z, Chen A, Chen J, Sekhon A, Louie G, Noel J, et al.
Chem Sci
. 2023 Oct;
14(39):10925-10933.
PMID: 37829009
Protein-reactive natural products such as the fungal metabolite cerulenin are recognized for their value as therapeutic candidates, due to their ability to selectively react with catalytic residues within a protein...
4.
Xie L, Bowman M, Louie G, Zhang C, Ardejani M, Huang X, et al.
Biochemistry
. 2023 Oct;
62(21):3050-3060.
PMID: 37813856
Over the past decade, advances in genomics have identified thousands of additional protein-coding small open reading frames (smORFs) missed by traditional gene finding approaches. These smORFs encode peptides and small...
5.
Mindrebo J, Chen A, Kim W, Re R, Davis T, Noel J, et al.
ACS Catal
. 2022 Oct;
11(12):6787-6799.
PMID: 36187225
Ketosynthases (KSs) catalyze carbon-carbon bond forming reactions in fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs utilize a two-step ping pong kinetic mechanism to carry out an overall decarboxylative...
6.
Chen A, Mindrebo J, Davis T, Kim W, Katsuyama Y, Jiang Z, et al.
Acta Crystallogr D Struct Biol
. 2022 Sep;
78(Pt 9):1171-1179.
PMID: 36048156
Ketosynthases (KSs) catalyse essential carbon-carbon bond-forming reactions in fatty-acid biosynthesis using a two-step, ping-pong reaction mechanism. In Escherichia coli, there are two homodimeric elongating KSs, FabB and FabF, which possess...
7.
Chen P, Adak S, Chekan J, Liscombe D, Miyanaga A, Bernhardt P, et al.
Biochemistry
. 2022 Aug;
61(17):1844-1852.
PMID: 35985031
Vanadium-dependent haloperoxidases (VHPOs) from bacteria differ from their counterparts in fungi, macroalgae, and other bacteria by catalyzing organohalogenating reactions with strict regiochemical and stereochemical control. While this group of enzymes...
8.
Aiyer S, Strutzenberg T, Bowman M, Noel J, Lyumkis D
J Vis Exp
. 2022 Jul;
(185).
PMID: 35848829
Single-particle analysis (SPA) by cryo-electron microscopy (cryo-EM) is now a mainstream technique for high-resolution structural biology. Structure determination by SPA relies upon obtaining multiple distinct views of a macromolecular object...
9.
Thomas S, Shin Y, La Clair J, Noel J
RSC Adv
. 2022 Apr;
11(26):15512-15518.
PMID: 35481209
Since the 1950's the Earth's natural carbon cycle has not sufficiently sequestrated excess atmospheric CO contributed by human activities. CO levels rose above 400 ppm in 2013 and are forecasted...
10.
Misson L, Mindrebo J, Davis T, Patel A, McCammon J, Noel J, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(39):24224-24233.
PMID: 32929027
Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of chain extensions in FAS...