Robert Lu
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Explore the profile of Robert Lu including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Martin A, Schabort J, Bartke-Croughan R, Tran S, Preetham A, Lu R, et al.
Genes Dev
. 2025 Feb;
PMID: 40015989
Mutations in the shelterin protein POT1 are associated with diverse cancers and thought to drive carcinogenesis by impairing POT1's suppression of aberrant telomere elongation. To classify clinical variants of uncertain...
2.
Martin A, Schabort J, Bartke-Croughan R, Tran S, Preetham A, Lu R, et al.
bioRxiv
. 2024 Sep;
PMID: 39229243
Mutations in the shelterin protein POT1 are associated with diverse cancers, but their role in cancer progression remains unclear. To resolve this, we performed deep scanning mutagenesis in POT1 locally...
3.
Wondisford A, Lee J, Lu R, Schuller M, Groslambert J, Bhargava R, et al.
Nat Struct Mol Biol
. 2024 May;
31(5):791-800.
PMID: 38714889
The recognition that DNA can be ADP ribosylated provides an unexpected regulatory level of how ADP-ribosylation contributes to genome stability, epigenetics and immunity. Yet, it remains unknown whether DNA ADP-ribosylation...
4.
Yang S, Nelson C, Wells J, Fernando M, Lu R, Allen J, et al.
Nat Commun
. 2024 Mar;
15(1):2210.
PMID: 38472229
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part...
5.
Nelson C, Rogers S, Roychoudhury K, Sing Tan Y, Atkinson C, Sobinoff A, et al.
Nat Commun
. 2024 Feb;
15(1):1385.
PMID: 38360978
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase...
6.
Lu R, Nelson C, Rogers S, Cesare A, Sobinoff A, Pickett H
iScience
. 2024 Jan;
27(1):108655.
PMID: 38213617
Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length. One of the defining features of ALT cells...
7.
Mack J, Klinth M, Martinsson S, Lu R, Stormer H, Hanington P, et al.
Mol Phylogenet Evol
. 2023 Mar;
182:107748.
PMID: 36858082
Freshwater annelids are globally widespread in aquatic ecosystems, but their diversity is severely underestimated. Obvious morphological features to define taxa are sparse, and molecular phylogenetic analyses regularly discover cryptic diversity...
8.
Lu R, Allen J, Galaviz P, Pickett H
STAR Protoc
. 2022 Mar;
3(1):101212.
PMID: 35265860
Alternative lengthening of telomeres (ALT) is a homologous recombination-based telomere maintenance mechanism. It is active in approximately 10-15% of cancers. We present a DNA-fiber protocol, combining YOYO-1 staining of genomic...
9.
Lu R, Pickett H
Open Biol
. 2022 Mar;
12(3):220011.
PMID: 35259951
Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate....
10.
Chen Y, Dagg R, Zhang Y, Lee J, Lu R, Martin La Rotta N, et al.
Cancers (Basel)
. 2021 Nov;
13(21).
PMID: 34771533
C-Circles, self-primed telomeric C-strand templates for rolling circle amplification, are the only known alternative-lengthening-of-telomeres (ALT)-specific molecule. However, little is known about the biology of C-Circles and if they may be...