Joshua A M Allen
Overview
Explore the profile of Joshua A M Allen including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
157
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Recent Articles
1.
Yang S, Nelson C, Wells J, Fernando M, Lu R, Allen J, et al.
Nat Commun
. 2024 Mar;
15(1):2210.
PMID: 38472229
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part...
2.
Lu R, Allen J, Galaviz P, Pickett H
STAR Protoc
. 2022 Mar;
3(1):101212.
PMID: 35265860
Alternative lengthening of telomeres (ALT) is a homologous recombination-based telomere maintenance mechanism. It is active in approximately 10-15% of cancers. We present a DNA-fiber protocol, combining YOYO-1 staining of genomic...
3.
Barroso-Gonzalez J, Garcia-Exposito L, Galaviz P, Lynskey M, Allen J, Hoang S, et al.
Cell Rep
. 2021 Dec;
37(10):110088.
PMID: 34879271
Alternative lengthening of telomeres (ALT) is a telomere-elongation mechanism observed in ∼15% of cancer subtypes. Current models indicate that ALT is mediated by homology-directed repair mechanisms. By disrupting MSH6 gene...
4.
Kychygina A, DallOsto M, Allen J, Cadoret J, Piras V, Pickett H, et al.
Sci Rep
. 2021 Jun;
11(1):13195.
PMID: 34162976
Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is...
5.
Kahl V, Allen J, Nelson C, Sobinoff A, Lee M, Kilo T, et al.
Front Cell Dev Biol
. 2020 Jul;
8:493.
PMID: 32612998
Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks....
6.
Lu R, ORourke J, Sobinoff A, Allen J, Nelson C, Tomlinson C, et al.
Nat Commun
. 2019 Nov;
10(1):5345.
PMID: 31745078
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
Lu R, ORourke J, Sobinoff A, Allen J, Nelson C, Tomlinson C, et al.
Nat Commun
. 2019 May;
10(1):2252.
PMID: 31138797
The collapse of stalled replication forks is a major driver of genomic instability. Several committed mechanisms exist to resolve replication stress. These pathways are particularly pertinent at telomeres. Cancer cells...