Alexander P Sobinoff
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Explore the profile of Alexander P Sobinoff including associated specialties, affiliations and a list of published articles.
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27
Citations
622
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Recent Articles
1.
Winstanley Y, Rose R, Sobinoff A, Wu L, Adhikari D, Zhang Q, et al.
Nat Commun
. 2025 Mar;
16(1):2527.
PMID: 40087268
The initial setting of telomere length during early life in each individual has a major influence on lifetime risk of aging-associated diseases; however there is limited knowledge of biological signals...
2.
Abbouche L, Murphy V, Gao J, van Twest S, Sobinoff A, Auweiler K, et al.
Nucleic Acids Res
. 2024 Aug;
52(18):11029-11044.
PMID: 39189453
FANCM is a DNA repair protein that recognizes stalled replication forks, and recruits downstream repair factors. FANCM activity is also essential for the survival of cancer cells that utilize the...
3.
Yang S, Nelson C, Wells J, Fernando M, Lu R, Allen J, et al.
Nat Commun
. 2024 Mar;
15(1):2210.
PMID: 38472229
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part...
4.
Nelson C, Rogers S, Roychoudhury K, Sing Tan Y, Atkinson C, Sobinoff A, et al.
Nat Commun
. 2024 Feb;
15(1):1385.
PMID: 38360978
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase...
5.
Lu R, Nelson C, Rogers S, Cesare A, Sobinoff A, Pickett H
iScience
. 2024 Jan;
27(1):108655.
PMID: 38213617
Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length. One of the defining features of ALT cells...
6.
Sobinoff A, Di Maro S, Low R, Benedetti R, Tomassi S, DAniello A, et al.
Cell Chem Biol
. 2023 Dec;
30(12):1652-1665.e6.
PMID: 38065101
The TRF2 shelterin component is an essential regulator of telomere homeostasis and genomic stability. Mutations in the TRF2 domain physically impair t-loop formation and prevent the recruitment of several factors...
7.
Bruedigam C, Porter A, Song A, Vroeg In de Wei G, Stoll T, Straube J, et al.
Nat Cancer
. 2023 Oct;
5(1):47-65.
PMID: 37904045
Telomerase enables replicative immortality in most cancers including acute myeloid leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in myelofibrosis and myelodysplastic syndromes. Here, we develop an...
8.
de Nonneville A, Salas S, Bertucci F, Sobinoff A, Adelaide J, Guille A, et al.
EMBO Mol Med
. 2022 Aug;
14(10):e15859.
PMID: 35920001
In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α-thalassemia/mental retardation syndrome X-linked (ATRX) gene is mutated...
9.
Kahl V, Allen J, Nelson C, Sobinoff A, Lee M, Kilo T, et al.
Front Cell Dev Biol
. 2020 Jul;
8:493.
PMID: 32612998
Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks....
10.
Sobinoff A, Pickett H
Curr Opin Genet Dev
. 2020 Mar;
60:25-30.
PMID: 32119936
Telomere maintenance is essential for the continued proliferation of mitotically active cells. Alternative Lengthening of Telomeres (ALT) is a recombination-dependent pathway of telomere maintenance analogous to break-induced replication (BIR) [1]...