Robert L Martuza
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Explore the profile of Robert L Martuza including associated specialties, affiliations and a list of published articles.
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85
Citations
7295
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Recent Articles
1.
Kardani K, Ghouse S, Din Abdul Jabbar M, Rajasubramanian N, Sanchez Gil J, Stemmer-Rachamimov A, et al.
Neurooncol Adv
. 2025 Feb;
7(1):vdae215.
PMID: 39896074
Background: Glioblastoma (GBM) treatment is hindered by a dearth of representative mouse GBM preclinical models in immunocompetent mice. Here, we characterized 5 murine GBM stem-like cell (mGSC) models derived from...
2.
Bommareddy P, Wakimoto H, Martuza R, Kaufman H, Rabkin S, Saha D
J Immunother Cancer
. 2024 Apr;
12(4).
PMID: 38599661
Background: Glioblastoma (GBM), a highly immunosuppressive and often fatal primary brain tumor, lacks effective treatment options. GBMs contain a subpopulation of GBM stem-like cells (GSCs) that play a central role...
3.
Shimizu K, Kahramanian A, Din Abdul Jabbar M, Turna Demir F, Gokyer D, Uthamacumaran A, et al.
Cancer Lett
. 2023 Aug;
572:216363.
PMID: 37619813
Oncolytic viruses (OVs) have emerged as a clinical therapeutic modality potentially effective for cancers that evade conventional therapies, including central nervous system malignancies. Rationally designed combinatorial strategies can augment the...
4.
Kawamura Y, Hua L, Gurtner A, Wong E, Kiyokawa J, Shah N, et al.
Biomed Pharmacother
. 2022 Oct;
155:113843.
PMID: 36271587
Approximately 20% of meningiomas are not benign (higher grade) and tend to relapse after surgery and radiation therapy. Malignant (anaplastic) meningioma (MM) is a minor subset of high-grade meningioma that...
5.
Jahan N, Ghouse S, Martuza R, Rabkin S
Viruses
. 2021 Sep;
13(9).
PMID: 34578321
Herpes simplex virus (HSV) can be genetically altered to acquire oncolytic properties so that oncolytic HSV (oHSV) preferentially replicates in and kills cancer cells, while sparing normal cells, and inducing...
6.
Li M, Li G, Kiyokawa J, Tirmizi Z, Richardson L, Ning J, et al.
Acta Neuropathol Commun
. 2020 Dec;
8(1):221.
PMID: 33308315
Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal components in many types of cancer. CAFs contribute to hallmarks of cancer such as proliferation, invasion and immunosuppressive tumor microenvironment,...
7.
Kiyokawa J, Kawamura Y, Ghouse S, Acar S, Barcin E, Martinez-Quintanilla J, et al.
Clin Cancer Res
. 2020 Dec;
27(3):889-902.
PMID: 33257429
Purpose: Extracellular matrix (ECM) component hyaluronan (HA) facilitates malignant phenotypes of glioblastoma (GBM), however, whether HA impacts response to GBM immunotherapies is not known. Herein, we investigated whether degradation of...
8.
Lee G, Lamba N, Niemierko A, Kim D, Chapman P, Loeffler J, et al.
Int J Radiat Oncol Biol Phys
. 2020 Aug;
109(1):252-266.
PMID: 32777336
Purpose: The optimal timing of adjuvant radiation therapy (RT) in the management of atypical meningiomas remains controversial. We compared the outcomes of atypical meningiomas managed with upfront adjuvant RT versus...
9.
Saha D, Rabkin S, Martuza R
J Immunother Cancer
. 2020 May;
8(1).
PMID: 32457126
Background: Temozolomide (TMZ) chemotherapy is a current standard of care for glioblastoma (GBM), however it has only extended overall survival by a few months. Because it also modulates the immune...
10.
Lamba N, Hwang W, Kim D, Niemierko A, Marciscano A, Mehan Jr W, et al.
World Neurosurg
. 2019 Oct;
133:e804-e812.
PMID: 31605839
Background: Histopathological grading of meningiomas is insufficient for optimal risk stratification. The purpose of the present study was to determine the prognostic value of atypical histopathological features across all nonmalignant...