Jay S Loeffler
Overview
Explore the profile of Jay S Loeffler including associated specialties, affiliations and a list of published articles.
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166
Citations
8997
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Recent Articles
1.
Wisdom A, Dyer M, Horick N, Yeap B, Miller K, Swearingen B, et al.
Pituitary
. 2023 Jul;
26(4):510-520.
PMID: 37477853
Purpose: The quality of life (QoL) impact of multidisciplinary treatment for patients with nonfunctioning pituitary macroadenomas (NFPMA) is unclear. We sought to investigate associations between patient factors, clinical data, and...
2.
Hwang W, Jagadeesh K, Guo J, Hoffman H, Yadollahpour P, Reeves J, et al.
Nat Genet
. 2022 Jul;
54(8):1178-1191.
PMID: 35902743
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform clinical management or therapeutic development. Here, we...
3.
Saraf A, Yock T, Niemierko A, Oh K, Curry W, Butler W, et al.
Neuro Oncol
. 2022 Jun;
24(12):2180-2189.
PMID: 35671386
Background: Medulloblastoma (MB) is a rare central nervous system malignancy of adults, with limited contemporary studies to define treatment guidelines and expected late toxicity. Methods: A single-center, retrospective study was...
4.
Saraf A, Pike L, Franck K, Horick N, Yeap B, Fullerton B, et al.
Neurosurgery
. 2022 Mar;
90(5):506-514.
PMID: 35229827
Background: Local management for vestibular schwannoma (VS) is associated with excellent local control with focus on preserving long-term serviceable hearing. Fractionated proton radiation therapy (FPRT) may be associated with greater...
5.
Shi D, Guo J, Hoffman H, Su J, Mino-Kenudson M, Barth J, et al.
Lancet Oncol
. 2022 Feb;
23(2):e62-e74.
PMID: 35114133
With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In this...
6.
Perni S, Bitterman D, Ryan J, Silver J, Mitchell E, Christensen S, et al.
J Natl Compr Canc Netw
. 2021 Dec;
19(12):1401-1406.
PMID: 34902830
Background: Philanthropic donations are important funding sources in academic oncology but may be vulnerable to implicit or explicit biases toward women. However, the influence of gender on donations has not...
7.
Durante M, Debus J, Loeffler J
Nat Rev Phys
. 2021 Dec;
3(12):777-790.
PMID: 34870097
Radiotherapy should have low toxicity in the entrance channel (normal tissue) and be very effective in cell killing in the target region (tumour). In this regard, ions heavier than protons...
8.
Koetsier K, Hensen E, Niemierko A, Dewyer N, Chapman P, Lamba N, et al.
Otol Neurotol
. 2021 Sep;
42(10):1560-1571.
PMID: 34538850
Objective: To assess the efficacy and toxicity of proton radiotherapy in vestibular schwannoma. Study Design: Retrospective chart review and volumetric MRI-analyses. Setting: Tertiary referral center. Patients: Vestibular schwannoma patients treated...
9.
Li W, Li S, Chen I, Liu Y, Ramjiawan R, Leung C, et al.
Radiat Oncol
. 2021 Mar;
16(1):48.
PMID: 33663521
Background: Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/neu + BC to...
10.
Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection
Guo J, Hoffman H, Shroff S, Chen P, Hwang P, Kim D, et al.
Clin Cancer Res
. 2021 Feb;
27(10):2807-2815.
PMID: 33632928
Purpose: Perineural invasion (PNI) is associated with aggressive tumor behavior, recurrence, and metastasis, and can influence the administration of adjuvant treatment. However, standard histopathologic examination has limited sensitivity in detecting...