Robert E MacKenzie
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Explore the profile of Robert E MacKenzie including associated specialties, affiliations and a list of published articles.
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13
Citations
276
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Recent Articles
1.
Sutton J, Clark D, Dunsdon S, Fenton G, Fillmore A, Harris N, et al.
Bioorg Med Chem Lett
. 2011 Dec;
22(3):1464-8.
PMID: 22177783
Novel deazaxanthine-based DPP-4 inhibitors have been identified that are potent (IC(50) <10nM) and highly selective versus other dipeptidyl peptidases. Their synthesis and SAR are reported, along with initial efforts to...
2.
Christensen K, MacKenzie R
Vitam Horm
. 2008 Sep;
79:393-410.
PMID: 18804703
Folate-mediated metabolism involves enzyme-catalyzed reactions that occur in the cytoplasmic, mitochondrial, and nuclear compartments in mammalian cells. Which of the folate-dependent enzymes are expressed in these compartments depends on the...
3.
Christensen K, Rohlicek C, Andelfinger G, Michaud J, Bigras J, Richter A, et al.
Hum Mutat
. 2008 Sep;
30(2):212-20.
PMID: 18767138
Methylenetetrahydrofolate dehydrogenase)methenyltetrahydrofolate cyclohydrolase)formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural...
4.
Christensen K, MacKenzie R
Bioessays
. 2006 May;
28(6):595-605.
PMID: 16700064
In eukaryotes, folate metabolism is compartmentalized between the cytoplasm and organelles. The folate pathways of mitochondria are adapted to serve the metabolism of the organism. In yeast, mitochondria support cytoplasmic...
5.
Patel H, Di Pietro E, Mejia N, MacKenzie R
Arch Biochem Biophys
. 2005 Sep;
442(1):133-9.
PMID: 16150419
Mouse fibroblasts in which the mthfd2 gene encoding mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase (NMDMC) was previously inactivated were infected with retroviral expression constructs of dehydrogenase/cyclohydrolase cDNA. Cellular fractionation confirmed that the...
6.
Christensen K, Mirza I, Berghuis A, MacKenzie R
J Biol Chem
. 2005 Aug;
280(40):34316-23.
PMID: 16100107
The mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase (NMDMC) is believed to have evolved from a trifunctional NADP-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase. It is unique in its absolute requirement for inorganic phosphate and magnesium ions...
7.
Christensen K, Patel H, Kuzmanov U, Mejia N, MacKenzie R
J Biol Chem
. 2004 Dec;
280(9):7597-602.
PMID: 15611115
The Mthfd1 gene encoding the cytoplasmic methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme (DCS) was inactivated in embryonic stem cells. The null embryonic stem cells were used to generate spontaneously immortalized fibroblast...
8.
Di Pietro E, Wang X, MacKenzie R
Biochim Biophys Acta
. 2004 Sep;
1674(1):78-84.
PMID: 15342116
Deletion of the gene encoding NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase (NMDMC) in mice was demonstrated previously to result in failure to establish definitive erythropoiesis in the developing liver. We examined the expression...
9.
Hilton J, Christensen K, Watkins D, Raby B, Renaud Y, de la Luna S, et al.
Hum Mutat
. 2003 Jun;
22(1):67-73.
PMID: 12815595
Glutamate formiminotransferase deficiency, an autosomal recessive disorder and the second most common inborn error of folate metabolism, is presumed to be due to defects in the bifunctional enzyme glutamate formiminotransferase-cyclodeaminase...
10.
Baggott J, MacKenzie R
Biochem J
. 2003 Jun;
374(Pt 3):773-8.
PMID: 12793858
The 5,10-methenyltetrahydrofolate (5,10-CH=H4folate) synthetase catalyses the physiologically irreversible formation of 5,10-CH=H4folate from 5-formyltetrahydrofolate (5-HCO-H4folate) and ATP. It is not clear how (or if) 5-HCO-H4folate is formed in vivo. Using a...