Karen E Christensen
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Explore the profile of Karen E Christensen including associated specialties, affiliations and a list of published articles.
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24
Citations
446
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Recent Articles
1.
Christensen K, Faquette M, Leclerc D, Keser V, Luan Y, Bennett-Firmin J, et al.
Nutrients
. 2025 Jan;
17(1.
PMID: 39796516
Background/objectives: The gene variant results in a thermolabile MTHFR enzyme associated with elevated plasma homocysteine in TT individuals. Health risks associated with the TT genotype may be modified by dietary...
2.
Martinez Duncker Rebolledo E, Chan D, Christensen K, Reagan A, Howell G, Rozen R, et al.
Mol Hum Reprod
. 2024 Feb;
30(4).
PMID: 38366926
5,10-Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a key role in providing methyl groups for DNA methylation, including during spermatogenesis. A common genetic variant in humans (MTHFR 677C>T) results...
3.
Leclerc D, Christensen K, Reagan A, Keser V, Luan Y, Malysheva O, et al.
Mol Nutr Food Res
. 2024 Feb;
68(5):e2300355.
PMID: 38327171
Scope: Disturbances in one-carbon metabolism contribute to nonalcoholic fatty liver disease (NAFLD) which encompasses steatosis, steatohepatitis, fibrosis, and cirrhosis. The goal is to examine impact of folate deficiency and the...
4.
Reagan A, Christensen K, Graham L, Bedwell A, Eldridge K, Speedy R, et al.
J Cereb Blood Flow Metab
. 2022 Sep;
42(12):2333-2350.
PMID: 36050860
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer's disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate reductase (MTHFR) is a...
5.
Christensen K, Malysheva O, Carlin S, Matias F, MacFarlane A, Jacobs R, et al.
Nutrients
. 2022 Jan;
14(1).
PMID: 35011003
Folate and choline are interconnected metabolically. The MTHFD1 R653Q SNP is a risk factor for birth defects and there are concerns that choline deficiency may interact with this SNP and...
6.
Leclerc D, Jelinek J, Christensen K, Issa J, Rozen R
J Nutr Biochem
. 2020 Nov;
88:108554.
PMID: 33220403
Food fortification with folic acid and increased use of vitamin supplements have raised concerns about high folic acid intake. We previously showed that high folic acid intake was associated with...
7.
Cosin-Tomas M, Luan Y, Leclerc D, Malysheva O, Lauzon N, Bahous R, et al.
Nutrients
. 2020 Jun;
12(6).
PMID: 32521649
Fifteen to 20% of pregnant women may exceed the recommended intake of folic acid (FA) by more than four-fold. This excess could compromise neurocognitive and motor development in offspring. Here,...
8.
Bidla G, Watkins D, Chery C, Froese D, Ells C, Kerachian M, et al.
Mol Genet Metab
. 2020 May;
130(3):179-182.
PMID: 32414565
MTHFD1 is a trifunctional protein containing 10-formyltetrahydrofolate synthetase, 5,10-methenyltetrahydrofolate cyclohydrolase and 5,10-methylenetetrahydrofolate dehydrogenase activities. It is encoded by MTHFD1 and functions in the cytoplasmic folate cycle where it is involved...
9.
Leclerc D, Christensen K, Cauvi O, Yang E, Fournelle F, Bahous R, et al.
Mol Nutr Food Res
. 2018 Nov;
63(3):e1801001.
PMID: 30408316
Scope: Dietary and genetic folate disturbances can lead to nonalcoholic fatty liver disease (NAFLD). A common variant in methylenetetrahydrofolate reductase (MTHFR 677C→T) causes mild MTHFR deficiency with lower 5-methyltetrahydrofolate for...
10.
Christensen K, Bahous R, Hou W, Deng L, Malysheva O, Arning E, et al.
J Nutr
. 2018 Apr;
148(4):501-509.
PMID: 29659962
Background: Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > ...