Robert C Wykes
Overview
Explore the profile of Robert C Wykes including associated specialties, affiliations and a list of published articles.
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16
Citations
358
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Recent Articles
1.
Mosneag I, Flaherty S, Wykes R, Allan S
Neuroscience
. 2023 Dec;
550:89-101.
PMID: 38065289
Animal models are an indispensable tool in the study of ischaemic stroke with hundreds of drugs emerging from the preclinical pipeline. However, all of these drugs have failed to translate...
2.
Blondiaux A, Jia S, Annamneedi A, Caliskan G, Nebel J, Montenegro-Venegas C, et al.
Neurobiol Dis
. 2023 Oct;
188:106324.
PMID: 37838005
Epilepsies are multifaceted neurological disorders characterized by abnormal brain activity, e.g. caused by imbalanced synaptic excitation and inhibition. The neural extracellular matrix (ECM) is dynamically modulated by physiological and pathophysiological...
3.
Khalil A, Shekh-Ahmad T, Kovac S, Wykes R, Horgen F, Fleig A, et al.
Epilepsia Open
. 2023 Jun;
8(3):1169-1174.
PMID: 37328275
Transient receptor potential cation subfamily M7 (TRPM7) channels are ion channels permeable to divalent cations. They are abundantly expressed with particularly high expression in the brain. Previous studies have highlighted...
4.
Seward E, Wykes R
Methods Mol Biol
. 2022 Oct;
2565:187-202.
PMID: 36205895
Research using membrane capacitance (C) measurements in adrenal chromaffin cells has transformed our understanding of the molecular mechanisms controlling regulated exocytosis. This is in part due to the exquisite temporal...
5.
Mulroe F, Lin W, MacKenzie-Gray Scott C, Aourz N, Fan Y, Coutts G, et al.
Dis Model Mech
. 2022 Sep;
15(10).
PMID: 36073607
Manipulating firing-rate neuronal homeostasis, which enables neurons to regulate their intrinsic excitability, offers an attractive opportunity to prevent seizures. However, to date, no drug-based interventions have been reported that manipulate...
6.
Hills K, Kostarelos K, Wykes R
Front Mol Neurosci
. 2022 Jul;
15:903115.
PMID: 35832394
Glioblastoma (GBM) is the most common and advanced form of primary malignant tumor occurring in the adult central nervous system, and it is frequently associated with epilepsy, a debilitating comorbidity....
7.
Wykes R, Khoo H, Caciagli L, Blumenfeld H, Golshani P, Kapur J, et al.
Epilepsia
. 2019 Jun;
60(7):1293-1305.
PMID: 31179547
Neuroimaging techniques applied to a variety of organisms-from zebrafish, to rodents to humans-can offer valuable insights into neuronal network properties and their dysfunction in epilepsy. A wide range of imaging...
8.
Snowball A, Chabrol E, Wykes R, Shekh-Ahmad T, Cornford J, Lieb A, et al.
J Neurosci
. 2019 Feb;
39(16):3159-3169.
PMID: 30755487
Refractory focal epilepsy is a devastating disease for which there is frequently no effective treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way involves irreversible changes...
9.
Chang B, Leite M, Snowball A, Lieb A, Chabrol E, Walker M, et al.
Dis Model Mech
. 2018 Nov;
11(12).
PMID: 30467223
Focal neocortical epilepsy is a common form of epilepsy and there is a need to develop animal models that allow the evaluation of novel therapeutic strategies to treat this type...
10.
Rossi L, Kullmann D, Wykes R
Front Cell Neurosci
. 2018 Apr;
12:82.
PMID: 29632475
Epilepsy research is rapidly adopting novel fluorescence optical imaging methods to tackle unresolved questions on the cellular and circuit mechanisms of seizure generation and evolution. State of the art two-photon...