Robert C Wykes
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Explore the profile of Robert C Wykes including associated specialties, affiliations and a list of published articles.
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16
Citations
358
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Recent Articles
11.
Dubey M, Brouwers E, Hamilton E, Stiedl O, Bugiani M, Koch H, et al.
Ann Neurol
. 2018 Feb;
83(3):636-649.
PMID: 29466841
Objective: Loss of function of the astrocyte-specific protein MLC1 leads to the childhood-onset leukodystrophy "megalencephalic leukoencephalopathy with subcortical cysts" (MLC). Studies on isolated cells show a role for MLC1 in...
12.
Rossi L, Wykes R, Kullmann D, Carandini M
Nat Commun
. 2017 Aug;
8(1):217.
PMID: 28794407
Focal epilepsy involves excessive cortical activity that propagates both locally and distally. Does this propagation follow the same routes as normal cortical activity? We pharmacologically induced focal seizures in primary...
13.
Wykes R, Kullmann D, Pavlov I, Magloire V
J Neurosci Methods
. 2015 Jun;
260:215-20.
PMID: 26072246
Background: Novel treatments for drug-resistant epilepsy are required. New Method: Optogenetics is a combination of optical and genetic methods used to control the activity of specific populations of excitable cells...
14.
Kullmann D, Schorge S, Walker M, Wykes R
Nat Rev Neurol
. 2014 Mar;
10(5):300-4.
PMID: 24638133
Epilepsy represents a major burden to society, not least because approximately 25% of patients do not respond satisfactorily to antiepileptic medication, and only a minority with pharmacoresistant epilepsy are eligible...
15.
Walker M, Schorge S, Kullmann D, Wykes R, Heeroma J, Mantoan L
Epilepsia
. 2013 Sep;
54 Suppl 6:43-5.
PMID: 24001071
Gene therapy in human disease has expanded rapidly in recent years with the development of safer and more effective viral vectors, and presents a novel approach to the treatment of...
16.
Wykes R, Heeroma J, Mantoan L, Zheng K, MacDonald D, Deisseroth K, et al.
Sci Transl Med
. 2012 Nov;
4(161):161ra152.
PMID: 23147003
Neocortical epilepsy is frequently drug-resistant. Surgery to remove the epileptogenic zone is only feasible in a minority of cases, leaving many patients without an effective treatment. We report the potential...