Robert C Reid
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Explore the profile of Robert C Reid including associated specialties, affiliations and a list of published articles.
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69
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1308
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Recent Articles
11.
Tng J, Lim J, Wu K, Lucke A, Xu W, Reid R, et al.
J Med Chem
. 2020 May;
63(11):5956-5971.
PMID: 32383881
AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clinical trials for multiple myeloma, leukemia, and lymphoma. It has few hydrogen bond donors and acceptors but is a...
12.
Das Gupta K, Shakespear M, Curson J, Murthy A, Iyer A, Hodson M, et al.
Cell Rep
. 2020 Feb;
30(8):2712-2728.e8.
PMID: 32101747
Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible aerobic glycolysis and macrophage inflammatory responses. A proteomic...
13.
Rowley J, Reid R, Poon E, Wu K, Lim J, Lohman R, et al.
J Med Chem
. 2020 Jan;
63(2):529-541.
PMID: 31910011
Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported...
14.
Loh Z, Fitzsimmons R, Reid R, Ramnath D, Clouston A, Gupta P, et al.
Br J Pharmacol
. 2019 Jun;
176(19):3775-3790.
PMID: 31236923
Background And Purpose: Chronic liver diseases feature excessive collagen and matrix protein deposition or crosslinking that characterises fibrosis, leads to scar tissue, and disrupts liver functions. There is no effective...
15.
Rawle D, Li D, Wu Z, Wang L, Choong M, Lor M, et al.
J Virol
. 2019 Mar;
93(12).
PMID: 30918071
HIV-1 replication requires direct interaction between HIV-1 reverse transcriptase (RT) and cellular eukaryotic translation elongation factor 1A (eEF1A). Our previous work showed that disrupting this interaction inhibited HIV-1 uncoating, reverse...
16.
Kim S, Redvers R, Chi L, Ling X, Lucke A, Reid R, et al.
Dis Model Mech
. 2018 May;
11(7).
PMID: 29784888
Breast cancer brain metastases remain largely incurable. Although several mouse models have been developed to investigate the genes and mechanisms regulating breast cancer brain metastasis, these models often lack clinical...
17.
Iyer A, Xu W, Reid R, Fairlie D
J Med Chem
. 2017 Oct;
61(8):3253-3276.
PMID: 28977749
Numerous diseases are driven by chronic inflammation, placing major burdens on our health systems. Controlling inflammation is an important preventative and therapeutic goal. Over 40 "Complement" proteins are produced in...
18.
Lohman R, Hamidon J, Reid R, Rowley J, Yau M, Halili M, et al.
Nat Commun
. 2017 Aug;
8(1):351.
PMID: 28839129
Complement C3a is an important protein in innate and adaptive immunity, but its specific roles in vivo remain uncertain because C3a degrades rapidly to form the C3a-desArg protein, which does...
19.
de Araujo A, Wu C, Wu K, Reid R, Durek T, Lim J, et al.
Bioconjug Chem
. 2017 Jun;
28(6):1669-1676.
PMID: 28562031
Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native...
20.
Mak J, Xu W, Reid R, Corbett A, Meehan B, Wang H, et al.
Nat Commun
. 2017 Mar;
8:14599.
PMID: 28272391
Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions of 5-amino-6-D-ribitylaminouracil (a vitamin B2 biosynthetic intermediate) with glycolysis metabolites such as methylglyoxal. Here we show superior...