Robert A Nicholas
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Explore the profile of Robert A Nicholas including associated specialties, affiliations and a list of published articles.
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78
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1890
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Recent Articles
1.
Helekal D, Mortimer T, Mukherjee A, Gentile G, Le Van A, Nicholas R, et al.
bioRxiv
. 2025 Feb;
PMID: 39975361
The dynamics of antimicrobial resistance in bacterial populations are informed by the fitness impact of genetic determinants of resistance and antibiotic pressure. However, estimates of real-world fitness impact have been...
2.
Stover E, Little M, Connolly K, Li L, Nicholas R, Sikora A, et al.
J Infect Dis
. 2024 Mar;
230(4):852-856.
PMID: 38526341
There is an urgent need for vaccines against Neisseria gonorrhoeae, the causative agent of gonorrhea. Vaccination with an outer membrane vesicle-based Neisseria meningitidis vaccine provides some protection from N. gonorrhoeae;...
3.
Turner J, Stratton C, Bala S, Cardenas Alvarez M, Nicholas R, Davies C
ACS Infect Dis
. 2024 Mar;
10(4):1298-1311.
PMID: 38446051
Effective treatment of gonorrhea is threatened by the increasing prevalence of strains resistant to the extended-spectrum cephalosporins (ESCs). Recently, we demonstrated the promise of the third-generation cephalosporin cefoperazone as an...
4.
Avian and Human Homologues of the P2Y Receptor: Pharmacological, Signaling, and Molecular Properties
Boyer J, Schachter J, Sromek S, Palmer R, Jacobson K, Nicholas R, et al.
Drug Dev Res
. 2024 Jan;
39(3-4):253-261.
PMID: 38235168
[Table: see text] The P2Y receptor on turkey erythrocyte membranes was the first P2 receptor to be shown to activate phospholipase C (PLC) in a strictly guanine nucleotide-dependent manner and...
5.
Zhao J, Cochrane C, Najeeb J, Gooden D, Sciandra C, Fan P, et al.
Sci Transl Med
. 2023 Aug;
15(708):eadf5668.
PMID: 37556556
The UDP-3--(-3-hydroxyacyl)--acetylglucosamine deacetylase LpxC is an essential enzyme in the biosynthesis of lipid A, the outer membrane anchor of lipopolysaccharide and lipooligosaccharide in Gram-negative bacteria. The development of LpxC-targeting antibiotics...
6.
Zhu W, Cardenas-Alvarez M, Tomberg J, Little M, Duncan J, Nicholas R
PLoS One
. 2023 Apr;
18(4):e0284062.
PMID: 37027389
Neisseria gonorrhoeae is a highly adapted human sexually transmitted pathogen that can cause symptomatic infections associated with localized inflammation as well as asymptomatic and subclinical infections, particularly in females. Gonococcal...
7.
Paul D, Blatt T, Schug W, Clark E, Kawano T, Mackman N, et al.
J Thromb Haemost
. 2023 Mar;
21(7):1891-1902.
PMID: 36958516
Background: The hemostatic plug formation at sites of vascular injury is strongly dependent on rapid platelet activation and integrin-mediated adhesion and aggregation. However, to prevent thrombotic complications, platelet aggregate formation...
8.
9.
McLaughlin J, Layton R, Watkins P, Nicholas R, Brouwer K
PLoS One
. 2022 Dec;
17(12):e0278297.
PMID: 36512576
Postgraduate trainees elevate the academic strength of institutions by conducting research, promoting innovation, securing grant funding, training undergraduate students, and building alliances. Rigorous and systematic program evaluation can help ensure...
10.
Fenton B, Tomberg J, Sciandra C, Nicholas R, Davies C, Zhou P
J Biol Chem
. 2021 Sep;
297(4):101188.
PMID: 34529975
Resistance to the extended-spectrum cephalosporin ceftriaxone in the pathogenic bacteria Neisseria gonorrhoeae is conferred by mutations in penicillin-binding protein 2 (PBP2), the lethal target of the antibiotic, but how these...