Robert A Grassucci
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Explore the profile of Robert A Grassucci including associated specialties, affiliations and a list of published articles.
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34
Citations
2705
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Recent Articles
1.
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, et al.
Nat Struct Mol Biol
. 2020 Jun;
27(7):625-634.
PMID: 32483338
Cyclic nucleotide-gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electrical signals in sensory receptors and neurons. The molecular conformational changes underpinning ligand activation are largely undefined. We...
2.
Carter S, Hampton C, Langlois R, Melero R, Farino Z, Calderon M, et al.
Sci Adv
. 2020 Apr;
6(14):eaay9572.
PMID: 32270040
The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to directly visualize ER dynamics in several secretory cell...
3.
Fu Z, Indrisiunaite G, Kaledhonkar S, Shah B, Sun M, Chen B, et al.
Nat Commun
. 2019 Jun;
10(1):2579.
PMID: 31189921
When the ribosome encounters a stop codon, it recruits a release factor (RF) to hydrolyze the ester bond between the peptide chain and tRNA. RFs have structural motifs that recognize...
4.
Qiu W, Fu Z, Xu G, Grassucci R, Zhang Y, Frank J, et al.
Proc Natl Acad Sci U S A
. 2018 Dec;
115(51):12985-12990.
PMID: 30509977
Membrane proteins function in native cell membranes, but extraction into isolated particles is needed for many biochemical and structural analyses. Commonly used detergent-extraction methods destroy naturally associated lipid bilayers. Here,...
5.
McGoldrick L, Singh A, Saotome K, Yelshanskaya M, Twomey E, Grassucci R, et al.
Nature
. 2017 Dec;
553(7687):233-237.
PMID: 29258289
Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues. Altered TRPV6 expression is associated with a variety of human...
6.
Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A
Nature
. 2017 Jul;
549(7670):60-65.
PMID: 28737760
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength, and dysregulation...
7.
Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A
Neuron
. 2017 May;
94(3):569-580.e5.
PMID: 28472657
Fast excitatory neurotransmission is mediated by AMPA-subtype ionotropic glutamate receptors (AMPARs). AMPARs, localized at post-synaptic densities, are regulated by transmembrane auxiliary subunits that modulate AMPAR assembly, trafficking, gating, and pharmacology....
8.
Feng X, Fu Z, Kaledhonkar S, Jia Y, Shah B, Jin A, et al.
Structure
. 2017 Mar;
25(4):663-670.e3.
PMID: 28286002
We describe a spraying-plunging method for preparing cryoelectron microscopy (cryo-EM) grids with vitreous ice of controllable, highly consistent thickness using a microfluidic device. The new polydimethylsiloxane (PDMS)-based sprayer was tested...
9.
Fu Z, Kaledhonkar S, Borg A, Sun M, Chen B, Grassucci R, et al.
Structure
. 2016 Nov;
24(12):2092-2101.
PMID: 27818103
Upon encountering a stop codon on mRNA, polypeptide synthesis on the ribosome is terminated by release factors, and the ribosome complex, still bound with mRNA and P-site-bound tRNA (post-termination complex,...
10.
Liu Z, Gutierrez-Vargas C, Wei J, Grassucci R, Ramesh M, Espina N, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(43):12174-12179.
PMID: 27791004
Ribosomes of trypanosomatids, a family of protozoan parasites causing debilitating human diseases, possess multiply fragmented rRNAs that together are analogous to 28S rRNA, unusually large rRNA expansion segments, and r-protein...