Robert A Grassucci
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Explore the profile of Robert A Grassucci including associated specialties, affiliations and a list of published articles.
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34
Citations
2705
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Recent Articles
11.
Liu Z, Gutierrez-Vargas C, Wei J, Grassucci R, Sun M, Espina N, et al.
Protein Sci
. 2016 Oct;
26(1):82-92.
PMID: 27750394
With the advance of new instruments and algorithms, and the accumulation of experience over decades, single-particle cryo-EM has become a pivotal part of structural biology. Recently, we determined the structure...
12.
des Georges A, Clarke O, Zalk R, Yuan Q, Condon K, Grassucci R, et al.
Cell
. 2016 Sep;
167(1):145-157.e17.
PMID: 27662087
The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca(2+)) release channel required for skeletal muscle contraction. Here, we present cryo-EM reconstructions of RyR1 in multiple functional states revealing the...
13.
Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A
Science
. 2016 Jul;
353(6294):83-6.
PMID: 27365450
AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to high cognitive processes such as learning and memory. In the brain, AMPAR trafficking, gating, and pharmacology is tightly...
14.
Marabini R, Carragher B, Chen S, Chen J, Cheng A, Downing K, et al.
J Struct Biol
. 2015 Apr;
190(3):348-59.
PMID: 25913484
Image formation in bright field electron microscopy can be described with the help of the contrast transfer function (CTF). In this work the authors describe the "CTF Estimation Challenge", called...
15.
Zalk R, Clarke O, des Georges A, Grassucci R, Reiken S, Mancia F, et al.
Nature
. 2014 Dec;
517(7532):44-9.
PMID: 25470061
Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca(2+)) from intracellular stores into the cytosol, which is essential for numerous cellular functions including excitation-contraction coupling in muscle. Lack of...
16.
des Georges A, Hashem Y, Unbehaun A, Grassucci R, Taylor D, Hellen C, et al.
Nucleic Acids Res
. 2013 Dec;
42(5):3409-18.
PMID: 24335085
Eukaryotic translation termination results from the complex functional interplay between two release factors, eRF1 and eRF3, in which GTP hydrolysis by eRF3 couples codon recognition with peptidyl-tRNA hydrolysis by eRF1....
17.
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
Hashem Y, des Georges A, Dhote V, Langlois R, Liao H, Grassucci R, et al.
Nature
. 2013 Nov;
503(7477):539-43.
PMID: 24185006
Hepatitis C virus (HCV) and classical swine fever virus (CSFV) messenger RNAs contain related (HCV-like) internal ribosome entry sites (IRESs) that promote 5'-end independent initiation of translation, requiring only a...
18.
Hashem Y, des Georges A, Dhote V, Langlois R, Liao H, Grassucci R, et al.
Cell
. 2013 May;
153(5):1108-19.
PMID: 23706745
Eukaryotic translation initiation begins with assembly of a 43S preinitiation complex. First, methionylated initiator methionine transfer RNA (Met-tRNAi(Met)), eukaryotic initiation factor (eIF) 2, and guanosine triphosphate form a ternary complex...
19.
Hashem Y, des Georges A, Fu J, Buss S, Jossinet F, Jobe A, et al.
Nature
. 2013 Feb;
494(7437):385-9.
PMID: 23395961
Ribosomes, the protein factories of living cells, translate genetic information carried by messenger RNAs into proteins, and are thus involved in virtually all aspects of cellular development and maintenance. The...
20.
Taylor D, Unbehaun A, Li W, Das S, Lei J, Liao H, et al.
Proc Natl Acad Sci U S A
. 2012 Oct;
109(45):18413-8.
PMID: 23091004
Eukaryotic translation termination results from the complex functional interplay between two eukaryotic release factors, eRF1 and eRF3, and the ribosome, in which GTP hydrolysis by eRF3 couples codon recognition with...