Maksim Osipov
Overview
Explore the profile of Maksim Osipov including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
108
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Recent Articles
1.
Yulyaningsih E, Suh J, Fanok M, Chau R, Solanoy H, Takahashi R, et al.
Elife
. 2024 Sep;
12.
PMID: 39287504
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores...
2.
Craig 2nd R, De Vicente J, Estrada A, Feng J, Lexa K, Canet M, et al.
J Med Chem
. 2024 Mar;
67(7):5758-5782.
PMID: 38511649
Eukaryotic translation initiation factor 2B (eIF2B) is a key component of the integrated stress response (ISR), which regulates protein synthesis and stress granule formation in response to cellular insult. Modulation...
3.
Craig 2nd R, Fox B, Hu C, Lexa K, Osipov M, Thottumkara A, et al.
J Med Chem
. 2022 Dec;
65(24):16290-16312.
PMID: 36469401
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative...
4.
Leger P, Hu D, Biannic B, Bui M, Han X, Karbarz E, et al.
J Med Chem
. 2020 Apr;
63(10):5398-5420.
PMID: 32302140
USP7 is a promising target for cancer therapy as its inhibition is expected to decrease function of oncogenes, increase tumor suppressor function, and enhance immune function. Using a structure-based drug...
5.
Trost B, Osipov M
Chemistry
. 2015 Sep;
21(46):16318-43.
PMID: 26353936
The communesin alkaloids are a diverse family of Penicillium-derived alkaloids. Their caged-polycyclic structure and intriguing biological profiles have made these natural products attractive targets for total synthesis. Similarly, the ascidian-derived...
6.
Trost B, Donckele E, Thaisrivongs D, Osipov M, Masters J
J Am Chem Soc
. 2015 Jan;
137(7):2776-84.
PMID: 25629592
We report the discovery, synthesis, and application of a new class of non-C2-symmetric phosphoramidite ligands derived from pyroglutamic acid for use in both oxidative and redox-neutral palladium-catalyzed asymmetric allylic alkylations...
7.
Trost B, Osipov M
Angew Chem Int Ed Engl
. 2013 Jul;
52(35):9176-81.
PMID: 23824625
No abstract available.
8.
Trost B, Osipov M, Dong G
Org Lett
. 2012 Apr;
14(9):2254-7.
PMID: 22506671
Pyrroles can serve as competent nucleophiles with meso electrophiles in the Pd-catalyzed asymmetric allylic alkylation. The products from this transformation were obtained as a single regio- and diastereomer in high...
9.
Trost B, Osipov M, Kaib P, Sorum M
Org Lett
. 2011 May;
13(12):3222-5.
PMID: 21615099
Acetoxy Meldrum's acid can serve as a versatile acyl anion equivalent in the Pd-catalyzed asymmetric allylic alkylation. The reaction of this nucleophile with various meso and racemic electrophiles afforded alkylated...
10.
Trost B, Schaffner B, Osipov M, Wilton D
Angew Chem Int Ed Engl
. 2011 Apr;
50(15):3548-51.
PMID: 21452369
No abstract available.