Rob J Vandebriel
Overview
Explore the profile of Rob J Vandebriel including associated specialties, affiliations and a list of published articles.
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86
Citations
1143
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Recent Articles
1.
Hargitai R, Parrakova L, Szatmari T, Monfort-Lanzas P, Galbiati V, Audouze K, et al.
Front Toxicol
. 2024 Aug;
6:1331803.
PMID: 39135743
Respiratory sensitization is a complex immunological process eventually leading to hypersensitivity following re-exposure to the chemical. A frequent consequence is occupational asthma, which may occur after long latency periods. Although...
2.
Vandebriel R, Hakkert B, Pennings J, Rossi L, Bichlmaier I, Bil W
Crit Rev Toxicol
. 2024 Jul;
54(7):476-484.
PMID: 39041360
The European Union (EU) Chemicals Strategy for Sustainability regards chemicals that affect the immune system among the most harmful ones. The Extended One-Generation Reproductive Toxicity study (EOGRTS; Organisation for Economic...
3.
David C, Vermeulen J, Gioria S, Vandebriel R, Liptrott N
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791527
Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate...
4.
Snapkow I, Smith N, Arnesdotter E, Beekmann K, Blanc E, Braeuning A, et al.
Front Toxicol
. 2024 Apr;
6:1339104.
PMID: 38654939
As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune...
5.
van Walstijn C, Verweij S, Care R, Rigsby P, Clapper E, Markey K, et al.
Vaccine
. 2023 Aug;
41(38):5603-5613.
PMID: 37527955
For the batch release of vaccines, potency release assays are required. Non-animal in vitro tests have numerous advantages and are preferred; however, several vaccines are still released using in vivo...
6.
Braakhuis H, Gremmer E, Bannuscher A, Drasler B, Keshavan S, Rothen-Rutishauser B, et al.
NanoImpact
. 2023 May;
31:100466.
PMID: 37209722
Background: The establishment of reliable and robust in vitro models for hazard assessment, a prerequisite for moving away from animal testing, requires the evaluation of model transferability and reproducibility. Lung...
7.
Application of KU812 cells for assessing complement activation related effects by nano(bio)materials
David C, de la Fonteyne-Blankestijn L, Vermeulen J, Plant-Hately A, Vandebriel R, Liptrott N
Biomed Pharmacother
. 2023 May;
163:114841.
PMID: 37167727
Immunocompatibility issues related to nano(bio)materials, particularly liposomal formulations, involving activation of the complement system have been relatively well described however, they highlight the importance of preclinical evaluation of such interactions....
8.
Minnema J, Vandebriel R, Boer K, Klerx W, de Jong W, Delmaar C
Small
. 2023 Feb;
19(21):e2207326.
PMID: 36828794
Physiologically-based kinetic (PBK) modeling is a valuable tool to understand the kinetics of nanoparticles (NPs) in vivo. However, estimating PBK parameters remains challenging and commonly requires animal studies. To develop...
9.
Bannuscher A, Schmid O, Drasler B, Rohrbasser A, Braakhuis H, Meldrum K, et al.
NanoImpact
. 2022 Nov;
28:100439.
PMID: 36402283
Air-liquid interface (ALI) lung cell models cultured on permeable transwell inserts are increasingly used for respiratory hazard assessment requiring controlled aerosolization and deposition of any material on ALI cells. The...
10.
Jennen D, van Herwijnen M, Jetten M, Vandebriel R, Keizers P, Geertsma R, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36361846
Usage of injectable dermal fillers applied for aesthetic purposes has extensively increased over the years. As such, the number of related adverse reactions has increased, including patients showing severe complications...