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Ritu Roydasgupta

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Recent Articles
1.
Snijders A, Hermsen M, Baughman J, Buffart T, Huey B, Gajduskova P, et al.
Genes Chromosomes Cancer . 2007 Oct; 47(1):71-83. PMID: 17943968
Tumors vary widely in chromosomal level genome instability. To gain a better understanding of the underlying defects which foster specific types of aberrations, we investigated the response of cells of...
2.
Yau C, Fedele V, Roydasgupta R, Fridlyand J, Hubbard A, Gray J, et al.
Breast Cancer Res . 2007 Sep; 9(5):R59. PMID: 17850661
Introduction: Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age at diagnosis has been shown to be an independent indicator of...
3.
Byrd K, Huey B, Roydasgupta R, Fridlyand J, Snijders A, Albertson D
Breast Cancer Res Treat . 2007 Jun; 109(1):47-54. PMID: 17588203
SKP1-cullin-F-box protein (SCF) type ubiquitin ligases degrade proteins controlling the G1/S transition. Deficiency for FBXW7 (also known as hCDC4), which encodes the F-box protein of the SCF type ubiquitin ligase...
4.
Gajduskova P, Snijders A, Kwek S, Roydasgupta R, Fridlyand J, Tokuyasu T, et al.
Genome Biol . 2007 Jun; 8(6):R120. PMID: 17584934
Background: Amplifications, regions of focal high-level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however, the...
5.
Chin K, DeVries S, Fridlyand J, Spellman P, Roydasgupta R, Kuo W, et al.
Cancer Cell . 2006 Dec; 10(6):529-41. PMID: 17157792
This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying associations between recurrent CNAs, gene expression, and clinical outcome in a set of...
6.
Trautmann K, Terdiman J, French A, Roydasgupta R, Sein N, Kakar S, et al.
Clin Cancer Res . 2006 Nov; 12(21):6379-85. PMID: 17085649
Purpose: The genomic instability in colon cancer can be divided into at least two major types, microsatellite instability (MSI) or chromosomal instability (CIN). Although initially felt to be mutually exclusive,...
7.
Thorns C, Bastian B, Pinkel D, Roydasgupta R, Fridlyand J, Merz H, et al.
Genes Chromosomes Cancer . 2006 Oct; 46(1):37-44. PMID: 17044049
Angioimmunoblastic T-cell lymphoma (AILT) is a histopathologically well-defined entity. However, despite a number of cytogenetic studies, the genetic basis of this lymphoma entity is not clear. Moreover, there is an...
8.
Blaveri E, Brewer J, Roydasgupta R, Fridlyand J, DeVries S, Koppie T, et al.
Clin Cancer Res . 2005 Oct; 11(19 Pt 1):7012-22. PMID: 16203795
Purpose: Bladder carcinogenesis is believed to follow alternative pathways of disease progression driven by an accumulation of genetic alterations. The purpose of this study was to evaluate associations between measures...