Richard W Birkinshaw
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Explore the profile of Richard W Birkinshaw including associated specialties, affiliations and a list of published articles.
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35
Citations
2279
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Recent Articles
1.
Li K, Yap Y, Moujalled D, Sumardy F, Khakham Y, Georgiou A, et al.
Sci Adv
. 2025 Mar;
11(10):eadr8146.
PMID: 40043112
Defective apoptosis mediated by B cell lymphoma 2 antagonist/killer (BAK) or B cell lymphoma 2-associated X protein (BAX) underlies various pathologies including autoimmune and degenerative conditions. On mitochondria, voltage-dependent anion...
2.
Yuan Z, van Delft M, Li M, Sumardy F, Smith B, Huang D, et al.
PLoS Biol
. 2024 May;
22(5):e3002617.
PMID: 38696533
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial...
3.
Calleja D, Kuchel N, Lu B, Birkinshaw R, Klemm T, Doerflinger M, et al.
Front Chem
. 2022 May;
10:861209.
PMID: 35494659
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2. The papain-like protease (PLpro) domain is part...
4.
Hodder A, Christensen J, Scally S, Triglia T, Ngo A, Birkinshaw R, et al.
Structure
. 2022 Apr;
30(7):947-961.e6.
PMID: 35460613
Plasmepsins IX (PMIX) and X (PMX) are essential aspartyl proteases for Plasmodium spp. egress, invasion, and development. WM4 and WM382 inhibit PMIX and PMX in Plasmodium falciparum and P. vivax....
5.
Robin A, Miller M, Iyer S, Shi M, Wardak A, Lio D, et al.
Cell Death Differ
. 2022 Mar;
29(9):1757-1768.
PMID: 35279694
Pro-apoptotic BAK and BAX are activated by BH3-only proteins to permeabilise the outer mitochondrial membrane. The antibody 7D10 also activates BAK on mitochondria and its epitope has previously been mapped...
6.
Yuan Z, Dewson G, Czabotar P, Birkinshaw R
Biochem Soc Trans
. 2021 Dec;
49(6):2787-2795.
PMID: 34913469
The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitochondrial apoptosis is a common feature of cancer cells, targeting protein-protein interactions...
7.
Sandow J, Tan I, Huang A, Masaldan S, Bernardini J, Wardak A, et al.
EMBO J
. 2021 Sep;
40(20):e107237.
PMID: 34523147
BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associates to damage mitochondria and cause cell death. However, the dynamic structural mechanisms...
8.
Scicluna K, Dewson G, Czabotar P, Birkinshaw R
Acta Crystallogr F Struct Biol Commun
. 2021 May;
77(Pt 5):140-147.
PMID: 33949974
The Atg8 protein family comprises the GABA type A receptor-associated proteins (GABARAPs) and microtubule-associated protein 1 light chains 3 (MAP1LC3s) that are essential mediators of autophagy. The LC3-interacting region (LIR)...
9.
Roy M, Vom A, Okamoto T, Smith B, Birkinshaw R, Yang H, et al.
J Med Chem
. 2021 Apr;
64(9):5447-5469.
PMID: 33904752
The BCL-2 family of proteins (including the prosurvival proteins BCL-2, BCL-X, and MCL-1) is an important target for the development of novel anticancer therapeutics. Despite the challenges of targeting protein-protein...
10.
Birkinshaw R, Iyer S, Lio D, Luo C, Brouwer J, Miller M, et al.
Mol Cell
. 2021 Apr;
81(10):2123-2134.e5.
PMID: 33794146
A body of data supports the existence of core (α2-α5) dimers of BAK and BAX in the oligomeric, membrane-perturbing conformation of these essential apoptotic effector molecules. Molecular structures for these...