Peter E Czabotar
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Explore the profile of Peter E Czabotar including associated specialties, affiliations and a list of published articles.
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98
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11006
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Recent Articles
1.
Li K, Yap Y, Moujalled D, Sumardy F, Khakham Y, Georgiou A, et al.
Sci Adv
. 2025 Mar;
11(10):eadr8146.
PMID: 40043112
Defective apoptosis mediated by B cell lymphoma 2 antagonist/killer (BAK) or B cell lymphoma 2-associated X protein (BAX) underlies various pathologies including autoimmune and degenerative conditions. On mitochondria, voltage-dependent anion...
2.
Davies K, Czabotar P, Murphy J
Curr Opin Struct Biol
. 2024 Jul;
88:102891.
PMID: 39059047
Necroptosis is a lytic form of programmed cell death implicated in inflammatory pathologies, leading to intense interest in the underlying mechanisms and therapeutic prospects. Here, we review our current structural...
3.
Yuan Z, van Delft M, Li M, Sumardy F, Smith B, Huang D, et al.
PLoS Biol
. 2024 May;
22(5):e3002617.
PMID: 38696533
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial...
4.
Subas Satish H, Iyer S, Shi M, Wong A, Fischer K, Wardak A, et al.
Cell Death Differ
. 2024 Apr;
31(6):711-721.
PMID: 38582955
BAX and BAK are pro-apoptotic members of the BCL2 family that are required to permeabilize the mitochondrial outer membrane. The proteins can adopt a non-activated monomeric conformation, or an activated...
5.
Miller M, Cowan A, Brouwer J, Smyth S, Peng L, Wardak A, et al.
FEBS J
. 2023 Dec;
291(11):2335-2353.
PMID: 38088212
The B-cell lymphoma 2 (BCL2) family members, BCL2-associated protein X (BAX) and BCL2 homologous antagonist killer (BAK), are required for programmed cell death via the mitochondrial pathway. When cells are...
6.
Meng Y, Garnish S, Davies K, Black K, Leis A, Horne C, et al.
Nat Commun
. 2023 Oct;
14(1):6804.
PMID: 37884510
The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of...
7.
Czabotar P, Garcia-Saez A
Nat Rev Mol Cell Biol
. 2023 Jul;
24(10):732-748.
PMID: 37438560
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as either promoters or inhibitors of cell death. The functional interplay and balance between the opposing BCL-2...
8.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
9.
Gardner C, Davies K, Zhang Y, Brzozowski M, Czabotar P, Murphy J, et al.
J Med Chem
. 2023 Feb;
66(4):2361-2385.
PMID: 36781172
Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an inflammatory phenotype. This process contributes profoundly to the pathophysiology of numerous neurodegenerative, cardiovascular, infectious, malignant, and...
10.
Meng Y, Horne C, Samson A, Dagley L, Young S, Sandow J, et al.
Cell Death Dis
. 2022 Jun;
13(6):565.
PMID: 35739084
Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3. To mediate necroptosis, RIPK3...