Richard M Weinshilboum
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Explore the profile of Richard M Weinshilboum including associated specialties, affiliations and a list of published articles.
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5171
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Recent Articles
11.
Zhu X, Gao H, Qin S, Liu D, Cairns J, Gu Y, et al.
Front Pharmacol
. 2022 Dec;
13:1047318.
PMID: 36518674
The cytochromes P450 (CYPs) represent a large gene superfamily that plays an important role in the metabolism of both exogenous and endogenous compounds. We have reported that the testis-specific Y-encoded-like...
12.
Wei L, Gao H, Yu J, Zhang H, Nguyen T, Gu Y, et al.
Cancer Res
. 2022 Dec;
83(3):456-470.
PMID: 36469363
Significance: The ratio of androgen receptor to estrogen receptor in breast cancer dictates the response to AR-targeted therapies, providing guidelines for developing AR-directed treatment strategies for patients with breast cancer.
13.
Nguyen T, Gao H, Liu D, Philips T, Ye Z, Lee J, et al.
Nucleic Acids Res
. 2022 Nov;
50(20):11635-11653.
PMID: 36399508
Understanding the function of non-coding genomic sequence variants represents a challenge for biomedicine. Many diseases are products of gene-by-environment interactions with complex mechanisms. This study addresses these themes by mechanistic...
14.
Ho M, Zhang C, Moon I, Zhu X, Coombes B, Biernacka J, et al.
Mol Psychiatry
. 2022 Oct;
29(6):1636-1646.
PMID: 36302966
The opioid epidemic represents a national crisis. Oxycodone is one of the most prescribed opioid medications in the United States, whereas buprenorphine is currently the most prescribed medication for opioid...
15.
Shivaram S, Gao H, Qin S, Liu D, Weinshilboum R, Wang L
Drug Metab Dispos
. 2022 Sep;
51(1):1-7.
PMID: 36153008
Cytochrome P450s () display significant inter-individual variation in expression, much of which remains unexplained by known single-nucleotide polymorphisms (SNPs). Testis-specific Y-encoded-like proteins (s) are transcriptional regulators for several drug-metabolizing including...
16.
Sicotte H, Kalari K, Qin S, Dehm S, Bhargava V, Gormley M, et al.
Mol Cancer Res
. 2022 Sep;
20(12):1739-1750.
PMID: 36135372
Implications: Finally, we identified candidates drugs to reverse AA/P resistance: topoisomerase inhibitors and drugs targeting the cell cycle via the MYC/AURKA/AURKB/TOP2A and/or PI3K_AKT_MTOR pathways.
17.
Nguyen T, Liu D, Gao H, Ye Z, Lee J, Wei L, et al.
Clin Transl Sci
. 2022 Sep;
15(11):2758-2771.
PMID: 36128656
Alternative polyadenylation (APA) is a common genetic regulatory mechanism that generates distinct 3' ends for RNA transcripts. Changes in APA have been associated with multiple biological processes and disease phenotypes....
18.
Ho M, Zhang C, Moon I, Coombes B, Biernacka J, Skime M, et al.
Front Pharmacol
. 2022 Sep;
13:986238.
PMID: 36120372
Acamprosate is an anti-craving drug used in alcohol use disorder (AUD) pharmacotherapy. However, only a subset of patients achieves optimal treatment outcomes. The identification of predictive biomarkers of acamprosate treatment...
19.
Gu Y, Gao H, Zhang H, John A, Zhu X, Shivaram S, et al.
Oncogene
. 2022 Jul;
41(35):4119-4129.
PMID: 35864174
The HER2 receptor modulates downstream signaling by forming homodimers and heterodimers with other members of the HER family. For patients with HER2-positive breast cancer, Trastuzumab, an anti-HER2 monoclonal antibody as...
20.
Thompson K, Leon-Ferre R, Sinnwell J, Zahrieh D, Suman V, Metzger F, et al.
NAR Cancer
. 2022 Jun;
4(2):zcac018.
PMID: 35734391
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with low overall survival rates and high molecular heterogeneity; therefore, few targeted therapies are available. The luminal androgen receptor...