Richard D Bagshaw
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Explore the profile of Richard D Bagshaw including associated specialties, affiliations and a list of published articles.
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22
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1901
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Recent Articles
1.
Muller P, Rademacher J, Bagshaw R, Wortmann C, Barth C, van Unen J, et al.
Nat Cell Biol
. 2020 Mar;
22(4):498-511.
PMID: 32203420
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are...
2.
Mahadevan V, Khademullah C, Dargaei Z, Chevrier J, Uvarov P, Kwan J, et al.
Elife
. 2017 Oct;
6.
PMID: 29028184
KCC2 is a neuron-specific K-Cl cotransporter essential for establishing the Cl gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where...
3.
Schlam D, Bagshaw R, Freeman S, Collins R, Pawson T, Fairn G, et al.
Nat Commun
. 2015 Oct;
6:8623.
PMID: 26465210
Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment...
4.
Abraham S, Scarcia M, Bagshaw R, McMahon K, Grant G, Harvey T, et al.
Nat Commun
. 2015 Jul;
6:7286.
PMID: 26129894
During angiogenesis, Rho-GTPases influence endothelial cell migration and cell-cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using...
5.
Tian R, Wang H, Gish G, Petsalaki E, Pasculescu A, Shi Y, et al.
Proc Natl Acad Sci U S A
. 2015 Apr;
112(13):E1594-603.
PMID: 25829543
Systematic characterization of intercellular signaling approximating the physiological conditions of stimulation that involve direct cell-cell contact is challenging. We describe a proteomic strategy to analyze physiological signaling mediated by the...
6.
Gray E, Petsalaki E, James D, Bagshaw R, Stacey M, Rocks O, et al.
J Biol Chem
. 2014 Oct;
289(51):35397-408.
PMID: 25331951
SH2D5 is a mammalian-specific, uncharacterized adaptor-like protein that contains an N-terminal phosphotyrosine-binding domain and a C-terminal Src homology 2 (SH2) domain. We show that SH2D5 is highly enriched in adult...
7.
Couzens A, Knight J, Kean M, Teo G, Weiss A, Dunham W, et al.
Sci Signal
. 2013 Nov;
6(302):rs15.
PMID: 24255178
The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell...
8.
Mellacheruvu D, Wright Z, Couzens A, Lambert J, St-Denis N, Li T, et al.
Nat Methods
. 2013 Aug;
10(8):730-6.
PMID: 23921808
Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for the identification of protein-protein interactions. However, for any given protein of interest, determining which of the identified...
9.
Findlay G, Smith M, Lanner F, Hsiung M, Gish G, Petsalaki E, et al.
Cell
. 2013 Mar;
152(5):1008-20.
PMID: 23452850
Metazoan evolution involves increasing protein domain complexity, but how this relates to control of biological decisions remains uncertain. The Ras guanine nucleotide exchange factor (RasGEF) Sos1 and its adaptor Grb2...
10.
Kaniuk N, Canadien V, Bagshaw R, Bakowski M, Braun V, Landekic M, et al.
Cell Microbiol
. 2011 Aug;
13(11):1812-23.
PMID: 21824248
The facultative intracellular pathogen Salmonella enterica serovar Typhimurium establishes a replicative niche, the Salmonella-containing vacuole (SCV), in host cells. Here we demonstrate that these bacteria exploit the function of Arl8B,...