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Evangelia Petsalaki

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Articles 46
Citations 2485
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Recent Articles
1.
Cai Y, Kanyo J, Wilson R, Bathla S, Cardozo P, Tong L, et al.
Nat Aging . 2025 Mar; PMID: 40065072
Dystrophic neurites (also termed axonal spheroids) are found around amyloid deposits in Alzheimer's disease (AD), where they impair axonal electrical conduction, disrupt neural circuits and correlate with AD severity. Despite...
2.
Hoff F, Sriraja L, Qiu Y, Jenkins G, Teachey D, Wood B, et al.
Cancers (Basel) . 2025 Jan; 16(24). PMID: 39766140
Background: The 5-year overall survival (OS) rates of T-cell lymphocytic leukemia (T-ALL) are better for children (>90%) compared to adults (~57%). The early T-cell precursor (ETP) T-ALL subtype is prognostically...
3.
Lussana A, Muller-Dott S, Saez-Rodriguez J, Petsalaki E
Bioinformatics . 2024 Nov; 40(12). PMID: 39563468
Summary: The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential drug targets. Identifying the kinases whose change in activity explains the...
4.
Nielsen M, Nohr-Meldgaard J, Mollerhoj M, Oro D, Pors S, Pors S, et al.
Am J Physiol Gastrointest Liver Physiol . 2024 Oct; 328(1):G51-G71. PMID: 39404770
The choline-deficient l-amino acid defined-high-fat diet (CDAA-HFD) mouse model is widely used in preclinical metabolic dysfunction-associated steatohepatitis (MASH) research. To validate the CDAA-HFD mouse, we evaluated disease progression and responsiveness...
5.
Tan J, Virtue S, Norris D, Conway O, Yang M, Bidault G, et al.
EMBO J . 2024 Sep; 43(19):4439. PMID: 39242789
No abstract available.
6.
Gomez J, Nolte H, Vogelsang E, Dey B, Takeda M, Giudice G, et al.
Elife . 2024 Sep; 13. PMID: 39221782
The initially homogeneous epithelium of the early embryo differentiates into regional subpopulations with different behaviours and physical properties that are needed for morphogenesis. The factors at top of the genetic...
7.
Vacca M, Kamzolas I, Harder L, Oakley F, Trautwein C, Hatting M, et al.
Nat Metab . 2024 Jun; 6(6):1178-1196. PMID: 38867022
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, encompasses steatosis and metabolic dysfunction-associated steatohepatitis (MASH), leading to cirrhosis and hepatocellular carcinoma. Preclinical MASLD research is...
8.
Giudice G, Chen H, Koutsandreas T, Petsalaki E
Mol Cell Proteomics . 2024 Apr; 23(6):100771. PMID: 38642805
Signaling networks are critical for virtually all cell functions. Our current knowledge of cell signaling has been summarized in signaling pathway databases, which, while useful, are highly biased toward well-studied...
9.
Tan J, Virtue S, Norris D, Conway O, Yang M, Bidault G, et al.
EMBO J . 2024 Apr; 43(11):2127-2165. PMID: 38580776
The in vitro oxygen microenvironment profoundly affects the capacity of cell cultures to model physiological and pathophysiological states. Cell culture is often considered to be hyperoxic, but pericellular oxygen levels,...
10.
Pinheiro-de-Sousa I, Fonseca-Alaniz M, Giudice G, Cordeiro Valadao I, Modestia S, Mattioli S, et al.
Mol Syst Biol . 2023 Nov; 19(12):e11462. PMID: 38031960
Endothelial dysfunction (ED) is critical in the development and progression of cardiovascular (CV) disorders, yet effective therapeutic targets for ED remain elusive due to limited understanding of its underlying molecular...