Richard D Bagshaw
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Explore the profile of Richard D Bagshaw including associated specialties, affiliations and a list of published articles.
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22
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1901
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Recent Articles
11.
Callahan J, Bagshaw R, Mahuran D
J Proteomics
. 2008 Dec;
72(1):23-33.
PMID: 19068244
The protein composition of the integral lysosomal membrane and the membrane-associated compartment have been defined in part by proteomics approaches. While the role of its constituent hydrolases in a large...
12.
Bukovac S, Bagshaw R, Rigat B, Callahan J, Clarke J, Mahuran D
Anal Biochem
. 2008 Jul;
381(2):276-8.
PMID: 18619939
The low levels of human lysosomal glucocerebrosidase activity expressed in transiently transfected Chinese hamster ovary (CHO) cells were investigated. Reverse transcription PCR (RT-PCR) demonstrated that a significant portion of the...
13.
Zhang H, Fan X, Bagshaw R, Zhang L, Mahuran D, Callahan J
J Proteome Res
. 2007 Jan;
6(1):240-9.
PMID: 17203968
Chediak-Higashi syndrome is characterized by dysfunctional giant organelles of common origin, that is, lysosomes, melanosomes, and platelet dense bodies. Its defective gene LYST encodes a large molecular weight protein whose...
14.
Fan X, Zhang H, Zhang S, Bagshaw R, Tropak M, Callahan J, et al.
Am J Hum Genet
. 2006 Sep;
79(4):738-44.
PMID: 16960811
Mucopolysaccharidosis IIIC (MPS IIIC), or Sanfilippo C, represents the only MPS disorder in which the responsible gene has not been identified; however, the gene has been localized to the pericentromeric...
15.
Bagshaw R, Callahan J, Mahuran D
Biochem Biophys Res Commun
. 2006 May;
344(4):1186-91.
PMID: 16650381
Lysosomes are late-endocytic organelles which primarily contribute to degradation and recycling of cellular material. From a previous proteomics study of purified rat liver lysosomal membranes we identified a protein from...
16.
Bagshaw R, Mahuran D, Callahan J
Mol Neurobiol
. 2005 Aug;
32(1):27-41.
PMID: 16077181
This review focuses on events involved in the biogenesis of the lysosome. This organelle contains a diverse array of soluble, luminal proteins capable of digesting all the macromolecules in the...
17.
Fan X, She Y, Bagshaw R, Callahan J, Schachter H, Mahuran D
Glycobiology
. 2005 May;
15(10):952-64.
PMID: 15888633
Hydrophobic proteins such as integral membrane proteins are difficult to separate, and therefore to study, at a proteomics level. However, the Asn-linked (N-linked) carbohydrates (N-glycans) contained in membrane glycoproteins are...
18.
Bagshaw R, Mahuran D, Callahan J
Mol Cell Proteomics
. 2004 Dec;
4(2):133-43.
PMID: 15579476
Lysosomes are endocytic subcellular compartments that contribute to the degradation and recycling of cellular material. Using highly purified rat liver tritosomes (Triton WR1339-filled lysosomes) and an ion exchange chromatography/LC-tandem MS-based...
19.
Arvanitis D, Wang H, Bagshaw R, Callahan J, Boggs J
J Neurosci Res
. 2004 Mar;
75(5):603-13.
PMID: 14991836
The estrogen receptor (ER) is a member of a superfamily of ligand-regulated transcription factors that were thought to localize primarily to the nucleus; however, a membrane-associated ER that can initiate...
20.
Pasternak S, Bagshaw R, Guiral M, Zhang S, Ackerley C, Pak B, et al.
J Biol Chem
. 2003 May;
278(29):26687-94.
PMID: 12736250
Alzheimer's disease (AD) is caused by the cerebral deposition of beta-amyloid (Abeta), a 38-43-amino acid peptide derived by proteolytic cleavage of the amyloid precursor protein (APP). Initial studies indicated that...