Ricardo Gallardo-Macias
Overview
Explore the profile of Ricardo Gallardo-Macias including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
275
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Recent Articles
11.
Lee W, Frey K, Gallardo-Macias R, Spasov K, Bollini M, Anderson K, et al.
ACS Med Chem Lett
. 2014 Nov;
5(11):1259-62.
PMID: 25408842
Catechol diethers that incorporate a 6-cyano-1-naphthyl substituent have been explored as non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Promising compounds are reported that show midpicomolar activity against the wild-type virus...
12.
Frey K, Gray W, Spasov K, Bollini M, Gallardo-Macias R, Jorgensen W, et al.
Chem Biol Drug Des
. 2013 Dec;
83(5):541-9.
PMID: 24289305
Using a computationally driven approach, a class of inhibitors with picomolar potency known as the catechol diethers were developed targeting the non-nucleoside-binding pocket of HIV-1 reverse transcriptase. Computational studies suggested...
13.
Lee W, Gallardo-Macias R, Frey K, Spasov K, Bollini M, Anderson K, et al.
J Am Chem Soc
. 2013 Oct;
135(44):16705-13.
PMID: 24151856
Members of the catechol diether class are highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). The most active compounds yield EC50 values below 0.5 nM in assays using human...
14.
Bollini M, Gallardo-Macias R, Spasov K, Tirado-Rives J, Anderson K, Jorgensen W
Bioorg Med Chem Lett
. 2013 Jan;
23(4):1110-3.
PMID: 23298809
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calculations. Optimization of the 4-R...
15.
Frey K, Bollini M, Mislak A, Cisneros J, Gallardo-Macias R, Jorgensen W, et al.
J Am Chem Soc
. 2012 Nov;
134(48):19501-3.
PMID: 23163887
X-ray crystal structures at 2.9 Å resolution are reported for two complexes of catechol diethers with HIV-1 reverse transcriptase. The results help elucidate the structural origins of the extreme antiviral...
16.
Bollini M, Domaoal R, Thakur V, Gallardo-Macias R, Spasov K, Anderson K, et al.
J Med Chem
. 2011 Nov;
54(24):8582-91.
PMID: 22081993
A 5-μM docking hit has been optimized to an extraordinarily potent (55 pM) non-nucleoside inhibitor of HIV reverse transcriptase. Use of free energy perturbation (FEP) calculations to predict relative free...