Ricardo Gallardo-Macias
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Explore the profile of Ricardo Gallardo-Macias including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
275
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Recent Articles
1.
Oncel S, Wang Q, Elsayed A, Vomhof-DeKrey E, Brown N, Golovko M, et al.
PLoS One
. 2024 Aug;
19(8):e0304010.
PMID: 39150901
M64HCl, which has drug-like properties, is a water-soluble Focal Adhesion Kinase (FAK) activator that promotes murine mucosal healing after ischemic or NSAID-induced injury. Since M64HCl has a short plasma half-life...
2.
Gallardo-Macias R, Russo R, Sherwood M, Jaskowski M, Nasser W, Sharma P, et al.
J Med Chem
. 2024 Jan;
67(2):1384-1392.
PMID: 38225186
Hospital-acquired infections, caused by ESKAPE bacteria, are a challenging global public health concern, in part due to the emergence of drug-resistant strains. While profiling a diverse set of compounds for...
3.
Wang Q, Gallardo-Macias R, Vomhof-DeKrey E, Gupta R, Golovko S, Golovko M, et al.
Curr Res Pharmacol Drug Discov
. 2023 Jan;
4:100147.
PMID: 36632414
Non-steroidal anti-inflammatory drugs (NSAIDs) injure the proximal and distal gut by different mechanisms. While many drugs reduce gastrointestinal injury, no drug directly stimulates mucosal wound healing. Focal adhesion kinase (FAK),...
4.
Rudraraju R, Daher S, Gallardo-Macias R, Wang X, Neiditch M, Freundlich J
Front Cell Infect Microbiol
. 2022 Oct;
12:1008213.
PMID: 36189349
Recent studies have reported the β-ketoacyl-acyl carrier protein KasA as a druggable target for . This review summarizes the current status of major classes of KasA inhibitors with an emphasis...
5.
Jadhav R, Gallardo-Macias R, Kumar G, Daher S, Kaushik A, Bigelow K, et al.
PLoS One
. 2021 May;
16(5):e0249841.
PMID: 33939697
We present further study of a subset of carbapenems, arising from a previously reported machine learning approach, with regard to their mouse pharmacokinetic profiling and subsequent study in a mouse...
6.
Wang Q, Gallardo-Macias R, Rashmi , Golovko M, Raafat Elsayed A, More S, et al.
ACS Med Chem Lett
. 2021 Mar;
12(3):356-364.
PMID: 33738062
Gastrointestinal mucosal wounds are common to patients injured by factors as diverse as drugs, inflammatory bowel disease, peptic ulcers, and necrotizing enterocolitis. However, although many drugs are used to ameliorate...
7.
Gallardo-Macias R, Kumar P, Jaskowski M, Richmann T, Shrestha R, Russo R, et al.
Bioorg Med Chem Lett
. 2019 Jan;
29(4):601-606.
PMID: 30600207
The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular...
8.
Chu J, Vila-Farres X, Inoyama D, Gallardo-Macias R, Jaskowski M, Satish S, et al.
ACS Infect Dis
. 2017 Aug;
4(1):33-38.
PMID: 28845973
The flippase MurJ is responsible for transporting the cell wall intermediate lipid II from the cytoplasm to the outside of the cell. While essential for the survival of bacteria, it...
9.
Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen L, Gordon E, et al.
Nat Chem Biol
. 2016 Oct;
12(12):1004-1006.
PMID: 27748750
Here we present a natural product discovery approach, whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacterial...
10.
Lee W, Frey K, Gallardo-Macias R, Spasov K, Chan A, Anderson K, et al.
Bioorg Med Chem Lett
. 2015 Jul;
25(21):4824-4827.
PMID: 26166629
Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that incorporate a 7-indolizinylamino or 2-naphthylamino substituent on a pyrimidine or 1,3,5-triazine core. The most potent compounds show below 10 nanomolar...