Reuben S E Young
Overview
Explore the profile of Reuben S E Young including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
187
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Recent Articles
1.
Mckinnon J, Balez R, Young R, Brown M, Lum J, Robinson L, et al.
J Am Soc Mass Spectrom
. 2024 Aug;
35(11):2729-2742.
PMID: 39137242
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can provide valuable insights into the metabolome of complex biological systems such as organ tissues and cells. However, obtaining metabolite data at single-cell...
2.
Brydon S, Poad B, Fang M, Rustam Y, Young R, Mouradov D, et al.
J Am Soc Mass Spectrom
. 2024 Jul;
35(8):1976-1990.
PMID: 39037040
The onset and progression of cancer is associated with changes in the composition of the lipidome. Therefore, better understanding of the molecular mechanisms of these disease states requires detailed structural...
3.
Benfield A, Vernen F, Young R, Nadal-Bufi F, Lamb H, Hammerlindl H, et al.
Pharmacol Res
. 2024 Jul;
207:107298.
PMID: 39032840
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and this is particularly true for patients with metastatic melanoma that carry a BRAF mutation. To address...
4.
Fan X, Sun A, Young R, Afara I, Hamilton B, Ong L, et al.
Bone Res
. 2024 Feb;
12(1):7.
PMID: 38311627
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, synovium, and adipose tissues. OA presents diverse clinical phenotypes and distinct molecular endotypes, including inflammatory, metabolic,...
5.
Michael J, Young R, Balez R, Jekimovs L, Marshall D, Poad B, et al.
Angew Chem Int Ed Engl
. 2024 Jan;
63(9):e202316793.
PMID: 38165069
In recent years there has been a significant interest in the development of innovative lipidomics techniques capable of resolving lipid isomers. To date, methods applied to resolving sn-isomers have resolved...
6.
Poad B, Jekimovs L, Young R, Wongsomboon P, Marshall D, Hansen F, et al.
Anal Chem
. 2023 Oct;
95(43):15917-15923.
PMID: 37847864
Many families of lipid isomers remain unresolved by contemporary liquid chromatography-mass spectrometry approaches, leading to a significant underestimation of the structural diversity within the lipidome. While ion mobility coupled to...
7.
Fan X, Young R, Sun A, Hamilton B, Nedunchezhiyan U, Crawford R, et al.
Theranostics
. 2023 Aug;
13(13):4636-4649.
PMID: 37649605
Enzymes are central components of many physiological processes, and changes in enzyme activity are linked to numerous disease states, including osteoarthritis (OA). Assessing changes in enzyme function can be challenging...
8.
Menzel J, Young R, Benfield A, Scott J, Wongsomboon P, Cudlman L, et al.
Nat Commun
. 2023 Jul;
14(1):3940.
PMID: 37402773
Fatty acid isomers are responsible for an under-reported lipidome diversity across all kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary analysis by incomplete separation and...
9.
Kirschbaum C, Young R, Greis K, Menzel J, Gewinner S, Schollkopf W, et al.
Chem Sci
. 2023 Mar;
14(10):2518-2527.
PMID: 36908944
Fatty acids are an abundant class of lipids that are characterised by wide structural variation including isomeric diversity arising from the position and configuration of functional groups. Traditional approaches to...
10.
Young R, Flakelar C, Narreddula V, Jekimovs L, Menzel J, Poad B, et al.
Anal Chem
. 2022 Nov;
94(46):16180-16188.
PMID: 36342869
Separation and identification of fatty acid (FA) isomers in biological samples represents a challenging problem for lipid chemists. Notably, FA regio- and stereo-isomers differing in the location or () geometry...