Martin C Sadowski
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Explore the profile of Martin C Sadowski including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
642
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Recent Articles
1.
Bidgood C, Philp L, Rockstroh A, Lehman M, Nelson C, Sadowski M, et al.
Cell Death Dis
. 2024 Jul;
15(7):513.
PMID: 39025852
Metabolic reprogramming and energetic rewiring are hallmarks of cancer that fuel disease progression and facilitate therapy evasion. The remodelling of oxidative phosphorylation and enhanced lipogenesis have previously been characterised as...
2.
April-Monn S, Kirchner P, Detjen K, Brautigam K, Trippel M, Grob T, et al.
NPJ Precis Oncol
. 2024 Mar;
8(1):59.
PMID: 38429350
There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous malignancy. We established patient-derived (PD) tumoroids from biobanked...
3.
Seiler K, Humbert M, Minder P, Mashimo I, Schlafli A, Krauer D, et al.
Cell Death Dis
. 2022 May;
13(5):448.
PMID: 35538058
The family of hexokinases (HKs) catalyzes the first step of glycolysis, the ATP-dependent phosphorylation of glucose to glucose-6-phosphate. While HK1 and HK2 are ubiquitously expressed, the less well-studied HK3 is...
4.
Young R, Bowman A, Tousignant K, Poad B, Gunter J, Philp L, et al.
J Lipid Res
. 2022 May;
63(6):100223.
PMID: 35537528
The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs...
5.
Laemmle A, Poms M, Hsu B, Borsuk M, Rufenacht V, Robinson J, et al.
Hepatology
. 2021 Nov;
76(3):646-659.
PMID: 34786702
Background And Aims: Patient-derived human-induced pluripotent stem cells (hiPSCs) differentiated into hepatocytes (hiPSC-Heps) have facilitated the study of rare genetic liver diseases. Here, we aimed to establish an in vitro...
6.
Wiegmans A, Ward A, Ivanova E, Duijf P, Adams M, Najib I, et al.
NAR Cancer
. 2021 Sep;
3(3):zcab041.
PMID: 34570837
[This corrects the article DOI: 10.1093/nar/zcab022.].
7.
Young R, Claes B, Bowman A, Williams E, Shepherd B, Perren A, et al.
Front Endocrinol (Lausanne)
. 2021 Aug;
12:689600.
PMID: 34421820
Prostate cancer is the fourth most common cancer worldwide with definitive diagnosis reliant on biopsy and human-graded histopathology. As with other pathologies, grading based on classical haematoxylin and eosin (H&E)...
8.
Wiegmans A, Ward A, Ivanova E, Duijf P, Adams M, Najib I, et al.
NAR Cancer
. 2021 Jul;
3(2):zcab022.
PMID: 34316709
Chemotherapy is used as a standard-of-care against cancers that display high levels of inherent genome instability. Chemotherapy induces DNA damage and intensifies pressure on the DNA repair pathways that can...
9.
Philp L, Rockstroh A, Sadowski M, Fard A, Lehman M, Tevz G, et al.
Endocr Relat Cancer
. 2021 Apr;
28(5):353-375.
PMID: 33794502
Hyperleptinaemia is a well-established therapeutic side effect of drugs inhibiting the androgen axis in prostate cancer (PCa), including main stay androgen deprivation therapy (ADT) and androgen targeted therapies (ATT). Given...
10.
Young R, Bowman A, Williams E, Tousignant K, Bidgood C, Narreddula V, et al.
Cell Rep
. 2021 Feb;
34(6):108738.
PMID: 33567271
Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation. Deep profiling of lipids across a range of prostate...