Reuben S E Young
Overview
Explore the profile of Reuben S E Young including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
187
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Recent Articles
11.
Young R, Bowman A, Tousignant K, Poad B, Gunter J, Philp L, et al.
J Lipid Res
. 2022 May;
63(6):100223.
PMID: 35537528
The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs...
12.
Poad B, Young R, Marshall D, Trevitt A, Blanksby S
Anal Chem
. 2022 Feb;
94(9):3897-3903.
PMID: 35201768
Gas-phase ion-molecule reactions provide structural insights across a range of analytical applications. A hindrance to the wider use of ion-molecule reactions is that they are relatively slow compared to other...
13.
Young R, Claes B, Bowman A, Williams E, Shepherd B, Perren A, et al.
Front Endocrinol (Lausanne)
. 2021 Aug;
12:689600.
PMID: 34421820
Prostate cancer is the fourth most common cancer worldwide with definitive diagnosis reliant on biopsy and human-graded histopathology. As with other pathologies, grading based on classical haematoxylin and eosin (H&E)...
14.
Claes B, Bowman A, Poad B, Young R, Heeren R, Blanksby S, et al.
Anal Chem
. 2021 Jul;
93(28):9826-9834.
PMID: 34228922
Mass spectrometry imaging (MSI) of lipids within tissues has significant potential for both biomolecular discovery and histopathological applications. Conventional MSI technologies are, however, challenged by the prevalence of phospholipid regioisomers...
15.
Young R, Bowman A, Williams E, Tousignant K, Bidgood C, Narreddula V, et al.
Cell Rep
. 2021 Feb;
34(6):108738.
PMID: 33567271
Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation. Deep profiling of lipids across a range of prostate...
16.
Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
Tousignant K, Rockstroh A, Poad B, Talebi A, Young R, Fard A, et al.
Cancer Metab
. 2020 Jun;
8:11.
PMID: 32577235
Background: Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, cancer cells are highly sensitive...
17.
Luginbuhl M, Young R, Stoeth F, Weinmann W, Blanksby S, Gaugler S
J Anal Toxicol
. 2020 Apr;
45(1):76-83.
PMID: 32248226
Phosphatidylethanol (PEth) in human blood samples is a marker for alcohol usage. Typically, PEth is detected by reversed-phase liquid chromatography coupled with negative ion tandem mass spectrometry, investigating the fatty...
18.
Poad B, Marshall D, Harazim E, Gupta R, Narreddula V, Young R, et al.
J Am Soc Mass Spectrom
. 2019 Jul;
30(10):2135-2143.
PMID: 31347025
The specific positions of carbon-carbon double bond(s) within an unsaturated fatty acid exert a significant effect on the physical and chemical properties of the lipid that ultimately inform its biological...
19.
Marshall D, Criscuolo A, Young R, Poad B, Zeller M, Reid G, et al.
J Am Soc Mass Spectrom
. 2019 Jun;
30(9):1621-1630.
PMID: 31222675
Over 1500 different lipids have been reported in human plasma at the sum composition level. Yet the number of unique lipids present is surely higher, once isomeric contributions from double...