Rene M Lemieux
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Explore the profile of Rene M Lemieux including associated specialties, affiliations and a list of published articles.
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5
Citations
182
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Recent Articles
1.
Chen Y, Nagaraja N, Fan B, Utley L, Lemieux R, Popovici-Muller J, et al.
Drug Metab Dispos
. 2021 Jul;
49(10):870-881.
PMID: 34321251
Point mutations in isocitrate dehydrogenase 1 () result in conversion of -ketoglutarate to the oncometabolite, d-2-hydroxyglutarate (2-HG). Ivosidenib is a once daily (QD), orally available, potent, mutant isocitrate dehydrogenase 1...
2.
Popovici-Muller J, Lemieux R, Artin E, Saunders J, Salituro F, Travins J, et al.
ACS Med Chem Lett
. 2018 Apr;
9(4):300-305.
PMID: 29670690
Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells,...
3.
Horan J, Kuzmich D, Liu P, Disalvo D, Lord J, Mao C, et al.
Bioorg Med Chem Lett
. 2015 Dec;
26(2):466-471.
PMID: 26687487
Poor solubility and cationic amphiphilic drug-likeness were liabilities identified for a lead series of S1P3-sparing, S1P1 agonists originally developed from a high-throughput screening campaign. This work describes the subsequent optimization...
4.
Horan J, Sanyal S, Choi Y, Hill-Drzewi M, Patnaude L, Anderson S, et al.
Bioorg Med Chem Lett
. 2014 Sep;
24(20):4807-11.
PMID: 25241927
The discovery of a new series of selective S1P1 agonists is described. This series of piperazinyl-oxadiazole derivatives was rapidly optimized starting from high-throughput screening hit 1 to afford potent and...
5.
Lemieux R, Devine P, Mechelke M, Meyers A
J Org Chem
. 2001 Oct;
64(10):3585-3591.
PMID: 11674485
Sequential allylation of chiral, nonracemic thiolactam 8 affords clean thio-Claisen [3,3] products 11. The stereoselectivity of the rearrangement was found to be on the order of 10-11:1, with the exo-endo...