Lynne C Bannen
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Explore the profile of Lynne C Bannen including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Horan J, Kuzmich D, Liu P, Disalvo D, Lord J, Mao C, et al.
Bioorg Med Chem Lett
. 2015 Dec;
26(2):466-471.
PMID: 26687487
Poor solubility and cationic amphiphilic drug-likeness were liabilities identified for a lead series of S1P3-sparing, S1P1 agonists originally developed from a high-throughput screening campaign. This work describes the subsequent optimization...
2.
Horan J, Sanyal S, Choi Y, Hill-Drzewi M, Patnaude L, Anderson S, et al.
Bioorg Med Chem Lett
. 2014 Sep;
24(20):4807-11.
PMID: 25241927
The discovery of a new series of selective S1P1 agonists is described. This series of piperazinyl-oxadiazole derivatives was rapidly optimized starting from high-throughput screening hit 1 to afford potent and...