Reidun Aesoy
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Explore the profile of Reidun Aesoy including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
185
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Recent Articles
1.
Khose G, Vagolu S, Aesoy R, Stefansson I, Rikhardsson S, Isleifsdottir D, et al.
Eur J Med Chem
. 2025 Jan;
285:117244.
PMID: 39788066
The natural bioactive products myxin and iodinin are phenazine 5,10-dioxides possessing potent anti-bacterial and anti-cancer activity in vitro. This work describes the synthesis and derivatization of new myxin and iodinin...
2.
Frazier T, Pereira E, Aesoy R, Nauton L, Giraud F, Herfindal L, et al.
Eur J Med Chem
. 2024 Mar;
269:116352.
PMID: 38537512
Pyrazole analogues of the staurosporine aglycone K252c, in which the lactam ring was replaced by a pyrazole moiety, were synthesized. In this series, one or the other nitrogen atoms of...
3.
Auvert E, Aesoy R, Giraud F, Herfindal L, Anizon F, Moreau P
Bioorg Med Chem Lett
. 2022 Aug;
73:128914.
PMID: 35917834
We synthesized new analogues of the anti-AML agent VS-II-173. We studied the effect of the substitution at the 1- and 5-positions of the pyrazolo[4,3-a]phenanthridine scaffold on Pim-1 kinase inhibition and...
4.
Slimestad R, Rathe B, Aesoy R, Carpinteyro Diaz A, Herfindal L, Fossen T
Sci Rep
. 2022 May;
12(1):7805.
PMID: 35551255
Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic...
5.
Fewer D, Jokela J, Heinila L, Aesoy R, Sivonen K, Galica T, et al.
Physiol Plant
. 2021 Jun;
173(2):639-650.
PMID: 34145585
Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty acid...
6.
Viktorsson E, Aesoy R, Stoa S, Lekve V, Doskeland S, Herfindal L, et al.
RSC Med Chem
. 2021 Jun;
12(5):767-778.
PMID: 34124675
Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin () and myxin () exhibit potent and...
7.
Skjanes K, Aesoy R, Herfindal L, Skomedal H
Physiol Plant
. 2021 Jun;
173(2):612-623.
PMID: 34085279
In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new...
8.
Solum E, Hansen T, Aesoy R, Herfindal L
Bioorg Med Chem
. 2020 Apr;
28(10):115461.
PMID: 32245563
Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of...
9.
Sivertsen Asrud K, Pedersen L, Aesoy R, Muwonge H, Aasebo E, Pettersen I, et al.
Sci Rep
. 2019 Sep;
9(1):13789.
PMID: 31551444
The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue...
10.
Bjornstad R, Aesoy R, Bruserud O, Brenner A, Giraud F, Dowling T, et al.
Mol Cancer Ther
. 2019 Jan;
18(3):567-578.
PMID: 30679386
More than 40 years ago, the present standard induction therapy for acute myeloid leukemia (AML) was developed. This consists of the metabolic inhibitor cytarabine (AraC) and the cytostatic topoisomerase 2...