Fabrice Anizon
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Explore the profile of Fabrice Anizon including associated specialties, affiliations and a list of published articles.
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59
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304
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Recent Articles
1.
Nerbo Reiten I, Giraud F, Augedal T, Forde J, Moreau P, Gundersen E, et al.
Int J Pharm
. 2024 Nov;
668:124989.
PMID: 39581514
The backbone of induction therapy in acute myeloid leukaemia (AML) is to use an anthracycline in combination with cytarabine. Despite recent advances in AML therapy, this treatment remains the standard,...
2.
Frazier T, Murail P, Boulange A, Chalane N, Giraud F, Artola A, et al.
RSC Med Chem
. 2024 Aug;
15(8):2900-2921.
PMID: 39149104
A series of 3,5-disubtituted pyridin-2(1)-ones was synthesized. As part of a structure-activity relationship study performed in this series, structural modifications were based on 3-(indol-4-yl)-5-(pyridin-4-ylamino)pyridin-2(1)-one B, which exhibited a potent anti-allodynic...
3.
Frazier T, Pereira E, Aesoy R, Nauton L, Giraud F, Herfindal L, et al.
Eur J Med Chem
. 2024 Mar;
269:116352.
PMID: 38537512
Pyrazole analogues of the staurosporine aglycone K252c, in which the lactam ring was replaced by a pyrazole moiety, were synthesized. In this series, one or the other nitrogen atoms of...
4.
Borisevich S, Aksinina T, Ilyina M, Shender V, Anufrieva K, Arapidi G, et al.
Cancers (Basel)
. 2024 Feb;
16(4).
PMID: 38398225
Serine-threonine protein kinases of the DYRK and CLK families regulate a variety of vital cellular functions. In particular, these enzymes phosphorylate proteins involved in pre-mRNA splicing. Targeting splicing with pharmacological...
5.
Defois M, Josselin B, Brindeau P, Kramer A, Knapp S, Anizon F, et al.
Bioorg Med Chem
. 2024 Feb;
100:117619.
PMID: 38320389
A structure-activity relationship study performed on 1H-pyrrolo[3,2-g]isoquinoline scaffold identified new haspin inhibitors with nanomolar potencies and selectivity indices (SI) over 6 (inhibitory potency evaluated against 8 protein kinases). Compound 22...
6.
Defois M, Remondin C, Josselin B, Nauton L, Thery V, Anizon F, et al.
Molecules
. 2022 Sep;
27(17).
PMID: 36080340
A new series of pyrazolo[3,4-]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine...
7.
Auvert E, Aesoy R, Giraud F, Herfindal L, Anizon F, Moreau P
Bioorg Med Chem Lett
. 2022 Aug;
73:128914.
PMID: 35917834
We synthesized new analogues of the anti-AML agent VS-II-173. We studied the effect of the substitution at the 1- and 5-positions of the pyrazolo[4,3-a]phenanthridine scaffold on Pim-1 kinase inhibition and...
8.
Zeinyeh W, Esvan Y, Josselin B, Defois M, Baratte B, Knapp S, et al.
Eur J Med Chem
. 2022 Apr;
236:114369.
PMID: 35447555
Haspin (haploid germ cell-specific nuclear protein kinase) offers a potential target for the development of new anticancer drugs. Thus, the identification of new inhibitors targeting this protein kinase is of...
9.
Visseq A, Descheemaeker A, Herault K, Giraud F, Abrunhosa-Thomas I, Artola A, et al.
Eur J Med Chem
. 2021 Aug;
225:113748.
PMID: 34392191
Mechanical allodynia, a painful sensation caused by innocuous touch, is a major chronic pain symptom, which often remains without an effective treatment. There is thus a need for new anti-allodynic...
10.
Giraud F, Pereira E, Anizon F, Moreau P
Molecules
. 2021 Jun;
26(9).
PMID: 34064521
The purpose of this review is to underline the protein kinases that have been established, either in fundamental approach or clinical trials, as potential biological targets in pain management. Protein...