Regina Irwin
Overview
Explore the profile of Regina Irwin including associated specialties, affiliations and a list of published articles.
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19
Citations
818
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0
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Recent Articles
1.
Chong Z, Huang F, McLeod M, Irwin R, Smithson M, Yue Z, et al.
Res Sq
. 2024 Jul;
PMID: 39011117
Background: Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer, but only 20-40% of patients completely respond to this treatment. Methods: To define the molecular features that...
2.
Smithson M, Irwin R, Williams G, Alexander K, Smythies L, Nearing M, et al.
J Biol Chem
. 2022 Jan;
298(3):101594.
PMID: 35041825
Locally advanced rectal cancer is typically treated with chemoradiotherapy followed by surgery. Most patients do not display a complete response to chemoradiotherapy, but resistance mechanisms are poorly understood. ST6GAL-1 is...
3.
Frydrych L, Ulintz P, Bankhead A, Sifuentes C, Greenson J, Maguire L, et al.
Neoplasia
. 2019 Sep;
21(10):1051-1062.
PMID: 31521947
Treatment of locally advanced rectal cancer includes chemotherapy, radiation, and surgery but patient responses to neoadjuvant treatment are variable. We have shown that rectal tumors are comprised of multiple genetically...
4.
McCabe L, Irwin R, Tekalur A, Evans C, Schepper J, Parameswaran N, et al.
Bone
. 2019 Aug;
127:677-678.
PMID: 31445666
No abstract available.
5.
McCabe L, Irwin R, Tekalur A, Evans C, Schepper J, Parameswaran N, et al.
Bone
. 2018 Apr;
118:20-31.
PMID: 29604350
High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents...
6.
Schepper J, Irwin R, Kang J, Dagenais K, Lemon T, Shinouskis A, et al.
Adv Exp Med Biol
. 2017 Nov;
1033:225-247.
PMID: 29101658
The intestinal environment is linked to an array of conditions and diseases, including osteoporosis. Human and animal studies indicate that probiotics can benefit intestinal health and may provide a useful...
7.
Porter A, Irwin R, Miller J, Horan D, Robling A, McCabe L
Sci Rep
. 2017 Feb;
7:42505.
PMID: 28198415
We have developed a straightforward method that uses paraffin-embedded bone for undemineralized thin sectioning, which is amenable to subsequent dynamic bone formation measurements. Bone has stiffer material properties than paraffin,...
8.
Irwin R, Raehtz S, Parameswaran N, McCabe L
Am J Physiol Regul Integr Comp Physiol
. 2016 Oct;
311(6):R1149-R1157.
PMID: 27733383
Increasing evidence indicates a strong link between intestinal health and bone health. For example, inflammatory bowel disease can cause systemic inflammation, weight loss, and extra-intestinal manifestations, such as decreased bone...
9.
Collins F, Irwin R, Bierhalter H, Schepper J, Britton R, Parameswaran N, et al.
PLoS One
. 2016 Apr;
11(4):e0153180.
PMID: 27058036
Background & Aims: We previously demonstrated that short-term oral administration of the probiotic Lactobacillus reuteri 6475 enhanced bone density in male but not female mice. We also established that L....
10.
Zhang J, Motyl K, Irwin R, MacDougald O, Britton R, McCabe L
Endocrinology
. 2015 Jul;
156(9):3169-82.
PMID: 26135835
Type 1 diabetes (T1D)-induced osteoporosis is characterized by a predominant suppression of osteoblast number and activity, as well as increased bone marrow adiposity but no change in osteoclast activity. The...