Rebecca Leyland
Overview
Explore the profile of Rebecca Leyland including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
786
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0
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Recent Articles
1.
Harper J, Burke S, Travers J, Rath N, Leinster A, Navarro C, et al.
Mol Cancer Ther
. 2021 Jul;
20(9):1723-1734.
PMID: 34224361
A recombinant Newcastle Disease Virus (NDV), encoding either a human (NDVhuGM-CSF, MEDI5395) or murine (NDVmuGM-CSF) GM-CSF transgene, combined broad oncolytic activity with the ability to significantly modulate genes related to...
2.
Hudson K, Cross N, Jordan-Mahy N, Leyland R
Front Immunol
. 2020 Nov;
11:568931.
PMID: 33193345
Programmed death-ligand 1 (PD-L1) is an immune checkpoint inhibitor that binds to its receptor PD-1 expressed by T cells and other immune cells to regulate immune responses; ultimately preventing exacerbated...
3.
Arbore G, Henley T, Biggins L, Andrews S, Vigorito E, Turner M, et al.
Life Sci Alliance
. 2019 May;
2(3).
PMID: 31097471
A fast antibody response can be critical to contain rapidly dividing pathogens. This can be achieved by the expansion of antigen-specific B cells in response to T-cell help followed by...
4.
Sheppard E, Morrish R, Dillon M, Leyland R, Chahwan R
Front Immunol
. 2018 Mar;
9:355.
PMID: 29535729
Epigenetic modifications, such as histone modifications, DNA methylation status, and non-coding RNAs (ncRNA), all contribute to antibody maturation during somatic hypermutation (SHM) and class-switch recombination (CSR). Histone modifications alter the...
5.
Leyland R, Watkins A, Mulgrew K, Holoweckyj N, Bamber L, Tigue N, et al.
Clin Cancer Res
. 2017 Jan;
23(13):3416-3427.
PMID: 28069723
To generate and characterize a murine GITR ligand fusion protein (mGITRL-FP) designed to maximize valency and the potential to agonize the GITR receptor for cancer immunotherapy. The EC value of...
6.
Mosely S, Prime J, Sainson R, Koopmann J, Wang D, Greenawalt D, et al.
Cancer Immunol Res
. 2016 Dec;
5(1):29-41.
PMID: 27923825
Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these models are still not clearly defined. The translational relevance of differences...
7.
Williams G, Mistry B, Guillard S, Coates Ulrichsen J, Sandercock A, Wang J, et al.
Oncotarget
. 2016 Sep;
7(42):68278-68291.
PMID: 27626702
Antibodies that target cell-surface molecules on T cells can enhance anti-tumor immune responses, resulting in sustained immune-mediated control of cancer. We set out to find new cancer immunotherapy targets by...
8.
Leyland R, Freedman D
Ann Clin Biochem
. 2016 Mar;
53(6):669-679.
PMID: 27013742
Background Lab Tests Online-UK celebrated its 10th anniversary in 2014 and to mark the occasion the first comprehensive survey of website users was undertaken. Methods A pop-up box with a...
9.
Nakagawa R, Leyland R, Meyer-Hermann M, Lu D, Turner M, Arbore G, et al.
J Clin Invest
. 2015 Dec;
126(1):377-88.
PMID: 26657861
The production of high-affinity antibodies by B cells is essential for pathogen clearance. Antibody affinity for antigen is increased through the affinity maturation in germinal centers (GCs). This is an...
10.
Tzoulis P, Evans R, Falinska A, Barnard M, Tan T, Woolman E, et al.
Postgrad Med J
. 2014 Nov;
90(1070):694-8.
PMID: 25398584
Purpose: Hyponatraemia is associated with significant morbidity and mortality. The objectives of this study were to evaluate the investigation and management of hyponatraemia and to assess the use of different...