Rebecca J Dearman
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Explore the profile of Rebecca J Dearman including associated specialties, affiliations and a list of published articles.
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116
Citations
1390
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Recent Articles
1.
Rane S, Dearman R, Kimber I, Derrick J
J Immunotoxicol
. 2022 Jan;
19(1):1-7.
PMID: 35077659
Biotherapeutic monoclonal antibodies (mAb) play important roles in clinical medicine but their potential to elicit immune responses in patients remains a major issue. In a study designed to investigate the...
2.
Browne T, Dearman R, Poles A
Int J Immunogenet
. 2020 Sep;
48(2):145-156.
PMID: 32970372
Granulocytes are an essential part of both the innate and adaptive immune systems. Human neutrophil antigens (HNAs) are a family of epitopes that are located on glycoproteins that are mostly...
3.
Gurjar S, Wheeler J, Wadhwa M, Thorpe R, Kimber I, Derrick J, et al.
J Biol Chem
. 2019 Nov;
294(51):19616-19634.
PMID: 31727737
Therapeutic mAbs are used to manage a wide range of cancers and autoimmune disorders. However, mAb-based treatments are not always successful, highlighting the need for a better understanding of the...
4.
Krutz N, Winget J, Ryan C, Wimalasena R, Maurer-Stroh S, Dearman R, et al.
Toxicol Sci
. 2019 Mar;
170(1):210-222.
PMID: 30903174
Use of botanicals and natural substances in consumer products has increased in recent years. Such extracts can contain protein that may theoretically represent a potential risk of IgE-mediated allergy. No...
5.
Wicks K, Stretton C, Popple A, Beresford L, Williams J, Maxwell G, et al.
Contact Dermatitis
. 2019 Feb;
81(1):43-53.
PMID: 30779159
Background: There is considerable interest in understanding the immunological variables that have the greatest influence on the effectiveness of sensitization by contact allergens, particularly in the context of developing new...
6.
Rane S, Dearman R, Kimber I, Uddin S, Bishop S, Shah M, et al.
Pharm Res
. 2019 Feb;
36(4):51.
PMID: 30771015
Purpose: Anti-drug antibodies can impair the efficacy of therapeutic proteins and, in some circumstances, induce adverse health effects. Immunogenicity can be promoted by aggregation; here we examined the ability of...
7.
Eyes T, Austerberry J, Dearman R, Johannissen L, Kimber I, Smith N, et al.
Mol Immunol
. 2018 Dec;
105:181-189.
PMID: 30550980
Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is...
8.
Pilkington S, Ogden S, Eaton L, Dearman R, Kimber I, Griffiths C
Immunology
. 2017 Aug;
153(1):60-70.
PMID: 28777886
Langerhans' cells (LC) play pivotal roles in skin immune responses, linking innate and adaptive immunity. In aged skin there are fewer LC and migration is impaired compared with young skin....
9.
Kheddo P, Bramham J, Dearman R, Uddin S, van der Walle C, Golovanov A
Mol Pharm
. 2017 Jun;
14(8):2852-2860.
PMID: 28614662
Liquid-liquid phase separation (LLPS) of monoclonal antibody (mAb) formulations involves spontaneous separation into dense (protein-rich) and diluted (protein-lean) phases and should be avoided in the final drug product. Understanding the...
10.
Gurjar S, Derrick J, Dearman R, Thorpe R, Hufton S, Kimber I, et al.
J Pharm Biomed Anal
. 2017 Jun;
143:188-198.
PMID: 28605680
Traditional antibody dependent cellular cytotoxicity (ADCC) assays use donor derived natural killer (NK) or peripheral blood mononuclear cells, but donor genetic variability and the technically challenging nature of the assay...