Rebeca Acin-Perez
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Explore the profile of Rebeca Acin-Perez including associated specialties, affiliations and a list of published articles.
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79
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4763
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Recent Articles
1.
Hernansanz-Agustin P, Morales-Vidal C, Calvo E, Natale P, Marti-Mateos Y, Jaroszewicz S, et al.
Cell Calcium
. 2024 Nov;
124:102971.
PMID: 39577329
In a comment to our recent publication, Nicholls question our results and interpretation based on theoretical arguments that reveal a profound misunderstanding of our publication.
2.
Hernansanz-Agustin P, Morales-Vidal C, Calvo E, Natale P, Marti-Mateos Y, Jaroszewicz S, et al.
Cell
. 2024 Sep;
187(23):6599-6613.e21.
PMID: 39303716
Eukaryotic cell function and survival rely on the use of a mitochondrial H electrochemical gradient (Δp), which is composed of an inner mitochondrial membrane (IMM) potential (ΔΨmt) and a pH...
3.
Rodriguez L, Alysandratos K, Katzen J, Murthy A, Roque Barboza W, Tomer Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38585863
Alveolar epithelial type II (AT2) cell dysfunction is implicated in the pathogenesis of familial and sporadic idiopathic pulmonary fibrosis (IPF). We previously described that expression of an AT2 cell exclusive...
4.
Brownstein A, Veliova M, Acin-Perez R, Villalobos F, Petcherski A, Tombolato A, et al.
Life Sci Alliance
. 2023 Dec;
7(2).
PMID: 38056907
Recent studies in brown adipose tissue (BAT) described a unique subpopulation of mitochondria bound to lipid droplets (LDs), which were termed PeriDroplet Mitochondria (PDM). PDM can be isolated from BAT...
5.
Palermo A, Li S, Hoeve J, Chellappa A, Morris A, Dillon B, et al.
Commun Biol
. 2023 Nov;
6(1):1115.
PMID: 37923961
The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate...
6.
Acin-Perez R, Montales K, Nguyen K, Brownstein A, Stiles L, Divakaruni A
Methods Mol Biol
. 2023 May;
2675:77-96.
PMID: 37258757
Methods for isolating mitochondria from different rodent tissues have been established for decades. Although the general principles for crude mitochondrial preparations are largely shared across tissues - tissue disruption followed...
7.
Zeng J, Acin-Perez R, Assali E, Martin A, Brownstein A, Petcherski A, et al.
Nat Commun
. 2023 May;
14(1):2573.
PMID: 37142604
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce autophagic...
8.
Fernandez-Del-Rio L, Beninca C, Villalobos F, Shu C, Stiles L, Liesa M, et al.
Life Sci Alliance
. 2023 Mar;
6(4).
PMID: 36918278
Mitochondrial depolarization can initiate reversal activity of ATP synthase, depleting ATP by its hydrolysis. We have recently shown that increased ATP hydrolysis contributes to ATP depletion leading to a maladaptation...
9.
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies
Acin-Perez R, Beninca C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, et al.
EMBO J
. 2023 Mar;
42(10):e111699.
PMID: 36912136
The maintenance of cellular function relies on the close regulation of adenosine triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is induced by loss of proton...
10.
Lechuga-Vieco A, Latorre-Pellicer A, Calvo E, Torroja C, Pellico J, Acin-Perez R, et al.
Circulation
. 2022 Mar;
145(14):1084-1101.
PMID: 35236094
Background: In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore...