Acisclo Perez-Martos
Overview
Explore the profile of Acisclo Perez-Martos including associated specialties, affiliations and a list of published articles.
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24
Citations
2040
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Recent Articles
1.
Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco A, Sanchez-Cabo F, Torroja C, Acin-Perez R, et al.
Nature
. 2016 Dec;
542(7639):124.
PMID: 27926738
No abstract available.
2.
Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco A, Sanchez-Cabo F, Torroja C, Acin-Perez R, et al.
Nature
. 2016 Jul;
535(7613):561-5.
PMID: 27383793
Human mitochondrial DNA (mtDNA) shows extensive within population sequence variability. Many studies suggest that mtDNA variants may be associated with ageing or diseases, although mechanistic evidence at the molecular level...
3.
Guaras A, Perales-Clemente E, Calvo E, Acin-Perez R, Loureiro-Lopez M, Pujol C, et al.
Cell Rep
. 2016 Apr;
15(1):197-209.
PMID: 27052170
Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the...
4.
Acin-Perez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernandez-Silva P, et al.
Cell Metab
. 2014 May;
19(6):1020-33.
PMID: 24856931
Electron flux in the mitochondrial electron transport chain is determined by the superassembly of mitochondrial respiratory complexes. Different superassemblies are dedicated to receive electrons derived from NADH or FADH2, allowing...
5.
Moreno-Loshuertos R, Perez-Martos A, Fernandez-Silva P, Enriquez J
FEBS J
. 2013 Aug;
280(20):4983-98.
PMID: 23910637
The efficiency of the cellular oxidative phosphorylation system was recently shown to be modulated by common mitochondrial tRNA(A) (rg) haplotypes. The molecular mechanism by which some mt-Tr haplotypes induce these...
6.
Lapuente-Brun E, Moreno-Loshuertos R, Acin-Perez R, Latorre-Pellicer A, Colas C, Balsa E, et al.
Science
. 2013 Jul;
340(6140):1567-70.
PMID: 23812712
The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as...
7.
Moreno-Loshuertos R, Ferrin G, Acin-Perez R, Gallardo M, Viscomi C, Perez-Martos A, et al.
PLoS Genet
. 2011 May;
7(4):e1001379.
PMID: 21533077
About half of the mitochondrial DNA (mtDNA) mutations causing diseases in humans occur in tRNA genes. Particularly intriguing are those pathogenic tRNA mutations than can reach homoplasmy and yet show...
8.
Bayona-Bafaluy M, Sanchez-Cabo F, Fernandez-Silva P, Perez-Martos A, Enriquez J
Mitochondrion
. 2011 Feb;
11(3):467-75.
PMID: 21292037
The mitochondrial oxidative phosphorylation (OxPhos) system produces most of the ATP required by the cell. The structural proteins of the OxPhos holoenzymes are well known, but important aspects of their...
9.
Fernandez-Vizarra E, Enriquez J, Perez-Martos A, Montoya J, Fernandez-Silva P
Mitochondrion
. 2010 Oct;
11(1):207-13.
PMID: 20933104
Each cell type develops and maintains a specific oxidative phosphorylation (OXPHOS) capacity to satisfy its metabolic and energetic demands. This implies that there are differences between tissues in mitochondrial number,...
10.
Perales-Clemente E, Fernandez-Silva P, Acin-Perez R, Perez-Martos A, Enriquez J
Nucleic Acids Res
. 2010 Sep;
39(1):225-34.
PMID: 20823090
Mitochondrial-DNA diseases have no effective treatments. Allotopic expression-synthesis of a wild-type version of the mutated protein in the nuclear-cytosolic compartment and its importation into mitochondria-has been proposed as a gene-therapy...