Orian S Shirihai
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Explore the profile of Orian S Shirihai including associated specialties, affiliations and a list of published articles.
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146
Citations
12924
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Recent Articles
1.
Wu B, Woo J, Hasiakos S, Pan C, Cokus S, Beninca C, et al.
Cell Rep
. 2025 Mar;
44(3):115430.
PMID: 40088449
Genetic and environmental factors shape an individual's susceptibility to autoimmunity. To identify genetic variations regulating effector T cell functions, we used a forward genetics screen of inbred mouse strains and...
2.
Levi-DAncona E, Walker E, Zhu J, Deng Y, Sidarala V, Stendahl A, et al.
bioRxiv
. 2025 Feb;
PMID: 39974969
Activation of innate immune signaling occurs during the progression of immunometabolic diseases, including type 2 diabetes (T2D), yet the impact of innate immune signaling on glucose homeostasis is controversial. Here,...
3.
Petcherski A, Tingley B, Martin A, Adams S, Brownstein A, Steinberg R, et al.
Life Sci Alliance
. 2025 Feb;
8(4).
PMID: 39900438
SARS-CoV-2 can infect cells through endocytic uptake, a process that is targeted by inhibition of lysosomal proteases. However, clinically this approach to treat viral infections has afforded mixed results, with...
4.
Ball A, Jones A, Nguyn K, Rios A, Marx N, Hsieh W, et al.
EMBO Rep
. 2025 Jan;
26(4):982-1002.
PMID: 39753784
Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Oxidative phosphorylation sharply decreases upon classical macrophage activation, as mitochondria are thought to shift from ATP...
5.
Hultgren N, Petcherski A, Torriano S, Komirisetty R, Sharma M, Zhou T, et al.
PNAS Nexus
. 2024 Dec;
3(12):pgae500.
PMID: 39712068
As the SARS-CoV-2 coronavirus continues to evolve and infect the global population, many individuals are likely to suffer from post-acute sequelae of SARS-CoV-2 infection (PASC). Manifestations of PASC include vision...
6.
Varuzhanyan G, Chen C, Freeland J, He T, Tran W, Song K, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2416882121.
PMID: 39589879
Adenocarcinomas from multiple tissues can converge to treatment-resistant small cell neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 subtypes. We investigated how mitochondrial metabolism influences SCN cancer (SCNC)...
7.
Taha M, Assali E, Ben-Kasus Nissim T, Stutzmann G, Shirihai O, Hershfinkel M, et al.
Mol Metab
. 2024 Jul;
87:101982.
PMID: 38960129
Objective: Hepatic Ca signaling has been identified as a crucial key factor in driving gluconeogenesis. The involvement of mitochondria in hormone-induced Ca signaling and their contribution to metabolic activity remain,...
8.
Lo C, OConnor L, Loi G, Saipuljumri E, Indajang J, Lopes K, et al.
ACS Nano
. 2024 Jun;
18(24):15452-15467.
PMID: 38830624
Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial impairments. Here, we report a series of...
9.
Ball A, Jones A, Nguyn K, Rios A, Marx N, Hsieh W, et al.
bioRxiv
. 2024 May;
PMID: 38798678
Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Upon classical macrophage activation, oxidative phosphorylation sharply decreases and mitochondria are repurposed to accumulate signals that...
10.
Rodriguez L, Alysandratos K, Katzen J, Murthy A, Roque Barboza W, Tomer Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38585863
Alveolar epithelial type II (AT2) cell dysfunction is implicated in the pathogenesis of familial and sporadic idiopathic pulmonary fibrosis (IPF). We previously described that expression of an AT2 cell exclusive...