Rea M Lardelli
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Explore the profile of Rea M Lardelli including associated specialties, affiliations and a list of published articles.
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7
Citations
233
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Recent Articles
1.
Ma T, Xiong E, Lardelli R, Lykke-Andersen J
Proc Natl Acad Sci U S A
. 2024 Jan;
121(3):e2315259121.
PMID: 38194449
Competing exonucleases that promote 3' end maturation or degradation direct quality control of small non-coding RNAs, but how these enzymes distinguish normal from aberrant RNAs is poorly understood. The Pontocerebellar...
2.
Ma T, Xiong E, Lardelli R, Lykke-Andersen J
bioRxiv
. 2023 Aug;
PMID: 37645788
Competing exonucleases that promote 3' end maturation or degradation direct quality control of small non-coding RNAs, but how these enzymes distinguish normal from aberrant RNAs is poorly understood. The Pontocerebellar...
3.
Lardelli R, Lykke-Andersen J
Genes Dev
. 2020 Jun;
34(13-14):989-1001.
PMID: 32499401
Polymerases and exonucleases act on 3' ends of nascent RNAs to promote their maturation or degradation but how the balance between these activities is controlled to dictate the fates of...
4.
Malone D, Lardelli R, Li M, David M
J Biol Chem
. 2019 Aug;
294(40):14674-14685.
PMID: 31395656
Human Schlafen 11 () is an interferon-stimulated gene (ISG) that we previously have demonstrated to ablate translation of HIV proteins based on the virus's distinct codon preference. Additionally, lack of...
5.
Lardelli R, Schaffer A, Eggens V, Zaki M, Grainger S, Sathe S, et al.
Nat Genet
. 2017 Jan;
49(3):457-464.
PMID: 28092684
Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg-dependent 3'-end RNases with substrate...
6.
Markmiller S, Cloonan N, Lardelli R, Doggett K, Keightley M, Boglev Y, et al.
Proc Natl Acad Sci U S A
. 2014 Feb;
111(8):3062-7.
PMID: 24516132
Minor class or U12-type splicing is a highly conserved process required to remove a minute fraction of introns from human pre-mRNAs. Defects in this splicing pathway have recently been linked...
7.
Lardelli R, Thompson J, Yates 3rd J, Stevens S
RNA
. 2010 Jan;
16(3):516-28.
PMID: 20089683
Eukaryotic pre-mRNA splicing is a complex process requiring the precise timing and action of >100 trans-acting factors. It has been known for some time that the two steps of splicing...